Synthetic lipoprotein as nano-material vehicle in the targeted drug delivery

• Main Authors: Xueqin Zhang, Gangliang Huang
• Format: Article
• Language: English
• Published: Taylor & Francis Group 2017-11-01
• Series: Drug Delivery
• Subjects: High-density lipoprotein; low-density lipoprotein; recombinant lipoprotein; nano-scaled vehicles; targeted drug delivery
• Online Access: http://dx.doi.org/10.1080/10717544.2017.1384518

High-density lipoprotein (HDL) and low-density lipoprotein (LDL), as human endogenous lipoprotein particles, have low toxicity, high selectivity, and good safety. They can avoid the recognition and clearance of human reticuloendothelial system. These synthetic lipoproteins (sLPs) have been attracted extensive attention as the nanovectors for tumor-targeted drug and gene delivery. Herein, recent advances in the field of anticancer based on these two lipid proteins and recombinant lipoproteins (rLPs) as target delivery vectors were analyzed and discussed.