GSK-3α Inhibition in Drug-Resistant CML Cells Promotes Susceptibility to NK Cell-Mediated Lysis in an NKG2D- and NKp30-Dependent Manner

GSK-3α Inhibition in Drug-Resistant CML Cells Promotes Susceptibility to NK Cell-Mediated Lysis in an NKG2D- and NKp30-Dependent Manner

Natural killer (NK) cells are innate cytotoxic lymphocytes that provide early protection against cancer. NK cell cytotoxicity against cancer cells is triggered by multiple activating receptors that recognize specific ligands expressed on target cells. We previously demonstrated that glycogen synthas...

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Bibliographic Details
Main Authors: Nayoung Kim, Mi Yeon Kim, Woo Seon Choi, Eunbi Yi, Hyo Jung Lee, Hun Sik Kim
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
natural killer cell
GSK-3α
NKG2D
NKp30
BCR-ABL1
Online Access:https://www.mdpi.com/2072-6694/13/8/1802

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