Bisoprolol responses (PK/PD) in hypertensive patients: A cytochrome P450 (CYP) 2D6 targeted polymorphism study

Bisoprolol responses (PK/PD) in hypertensive patients: A cytochrome P450 (CYP) 2D6 targeted polymorphism study

Background: Bisoprolol is an effective β1-adrenergic blocker, an inter-individual genetic variability was recorded in its response. This study aimed at investigating the association of CYP2D6*2A (rs1080985) and CYP2D6*10 (rs1065852) single-nucleotide polymorphism (SNP) with Bisoprolol response in ca...

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Bibliographic Details
Main Authors: Huda Mohammed Alkreathy, Khlood Mohammed Eid Alsayyid, Jumana Y. Alaama, Kamal Al Ghalayini, Shahid Karim, Ahmed Esmat, Zoheir A. Damanhouri
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Saudi Journal of Biological Sciences
Subjects:
Bisoprolol
CYP2D6*10
CYP2D6*2A
Hypertension
Genotyping
Online Access:http://www.sciencedirect.com/science/article/pii/S1319562X20302606

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