Inhibition of IL-10 production by maternal antibodies against Group B Streptococcus GAPDH confers immunity to offspring by favoring neutrophil recruitment.

Inhibition of IL-10 production by maternal antibodies against Group B Streptococcus GAPDH confers immunity to offspring by favoring neutrophil recruitment.

Group B Streptococcus (GBS) is the leading cause of neonatal pneumonia, septicemia, and meningitis. We have previously shown that in adult mice GBS glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an extracellular virulence factor that induces production of the immunosuppressive...

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Main Authors: Pedro Madureira, Elva Bonifácio Andrade, Bernardo Gama, Liliana Oliveira, Susana Moreira, Adília Ribeiro, Margarida Correia-Neves, Patrick Trieu-Cuot, Manuel Vilanova, Paula Ferreira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-11-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3219712?pdf=render

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