Ischemia reperfusion injury promotes recurrence of hepatocellular carcinoma in fatty liver via ALOX12-12HETE-GPR31 signaling axis

Ischemia reperfusion injury promotes recurrence of hepatocellular carcinoma in fatty liver via ALOX12-12HETE-GPR31 signaling axis

Abstract Background Ischemia reperfusion injury (IRI) has been shown to increase the risk of tumor recurrence after liver surgery. Also, nonalcoholic fatty liver disease (NAFLD) is associated with increased HCC recurrence. ALOX12–12-HETE pathway is activated both in liver IRI and NASH. Also, ALOX12–...

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Bibliographic Details
Main Authors: Faji Yang, Yuheng Zhang, Haozhen Ren, Jinglin Wang, Longcheng Shang, Yang Liu, Wei Zhu, Xiaolei Shi
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Ischemia reperfusion injury
ALOX12
12-HETE
HCC recurrence
GRP31
Online Access:https://doi.org/10.1186/s13046-019-1480-9

Internet

https://doi.org/10.1186/s13046-019-1480-9

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