Mechanistic studies on percutaneous penetration enhancement by N-(4-halobenzoyl)-S,S-dimethyliminosulfuranes

Mechanistic studies on percutaneous penetration enhancement by N-(4-halobenzoyl)-S,S-dimethyliminosulfuranes

Halogen-substituted iminosulfuranes are transdermal penetration enhancers (TPEs) in permeation studies using hairless mouse or human cadaver skin. The interaction of N-(4-R-benzoyl)-S,S-dimethyliminosulfuranes 1-4, where R = H, Cl, Br, and I, with l-α-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) h...

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Bibliographic Details
Main Authors: D.J. Barrow, Jr., S. Chandrasekaran, H.H. Heerklotz, M.M. Henary, B.B. Michniak, P.M. Nguyen, Y. Song, J.C. Smith, L. Strekowski
Format: Article
Language:English
Published: Elsevier 2005-10-01
Series:Journal of Lipid Research
Subjects:
transdermal penetration enhancer
vesicle
bilayer
nuclear magnetic resonance
calorimetry
polarizability
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520329102

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