An expedient and new synthesis of pyrrolo[1,2-b]pyridazine derivatives

An expedient and new synthesis of pyrrolo[1,2-b]pyridazine derivatives

The reaction of 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide with tertiary butyl carbazate and subsequent condensation of the resulting carbamate derivative with a chalcone provided a facile new approach to pyrrolo[1,2-b]pyridazine derivatives.

Bibliographic Details
Main Authors: Rajeshwar Reddy Sagyam, Ravinder Buchikonda, Jaya Prakash Pitta, Himabindu Vurimidi, Pratap Reddy Padi, Mahesh Reddy Ghanta
Format: Article
Language:English
Published: Beilstein-Institut 2009-11-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
1,4-diketone
migration and cyclization
pyrrolo[1,2-b]pyridazine
tertiary butyl carbamate
tertiary butyl carbazate
α,β-unsaturated ketone
Online Access:https://doi.org/10.3762/bjoc.5.66
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spelling doaj-34fe30aa415d4cee89a639e1b453d81d2021-03-02T09:40:29ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972009-11-01516610.3762/bjoc.5.661860-5397-5-66An expedient and new synthesis of pyrrolo[1,2-b]pyridazine derivativesRajeshwar Reddy Sagyam0Ravinder Buchikonda1Jaya Prakash Pitta2Himabindu Vurimidi3Pratap Reddy Padi4Mahesh Reddy Ghanta5Integrated Product Development, Dr. Reddy’s Laboratories Limited, Bachupally, Qutubullapur, Ranga Reddy District-500072, Andhra Pradesh, IndiaIntegrated Product Development, Dr. Reddy’s Laboratories Limited, Bachupally, Qutubullapur, Ranga Reddy District-500072, Andhra Pradesh, IndiaIntegrated Product Development, Dr. Reddy’s Laboratories Limited, Bachupally, Qutubullapur, Ranga Reddy District-500072, Andhra Pradesh, IndiaInstitute of Science and Technology, Center for Environmental Science, J. N. T. University, Kukatpally, Hyderabad-500 072, Andhra Pradesh, IndiaIntegrated Product Development, Dr. Reddy’s Laboratories Limited, Bachupally, Qutubullapur, Ranga Reddy District-500072, Andhra Pradesh, IndiaAsha Laboratories, Plot # 175/1, Prashanthi Nagar, Kukatpally, Hyderabad-500072, Andhra Pradesh, IndiaThe reaction of 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide with tertiary butyl carbazate and subsequent condensation of the resulting carbamate derivative with a chalcone provided a facile new approach to pyrrolo[1,2-b]pyridazine derivatives.https://doi.org/10.3762/bjoc.5.661,4-diketonemigration and cyclizationpyrrolo[1,2-b]pyridazinetertiary butyl carbamatetertiary butyl carbazateα,β-unsaturated ketone
collection DOAJ
language English
format Article
sources DOAJ
author Rajeshwar Reddy Sagyam
Ravinder Buchikonda
Jaya Prakash Pitta
Himabindu Vurimidi
Pratap Reddy Padi
Mahesh Reddy Ghanta
spellingShingle Rajeshwar Reddy Sagyam
Ravinder Buchikonda
Jaya Prakash Pitta
Himabindu Vurimidi
Pratap Reddy Padi
Mahesh Reddy Ghanta
An expedient and new synthesis of pyrrolo[1,2-b]pyridazine derivatives
Beilstein Journal of Organic Chemistry
1,4-diketone
migration and cyclization
pyrrolo[1,2-b]pyridazine
tertiary butyl carbamate
tertiary butyl carbazate
α,β-unsaturated ketone
author_facet Rajeshwar Reddy Sagyam
Ravinder Buchikonda
Jaya Prakash Pitta
Himabindu Vurimidi
Pratap Reddy Padi
Mahesh Reddy Ghanta
author_sort Rajeshwar Reddy Sagyam
title An expedient and new synthesis of pyrrolo[1,2-b]pyridazine derivatives
title_short An expedient and new synthesis of pyrrolo[1,2-b]pyridazine derivatives
title_full An expedient and new synthesis of pyrrolo[1,2-b]pyridazine derivatives
title_fullStr An expedient and new synthesis of pyrrolo[1,2-b]pyridazine derivatives
title_full_unstemmed An expedient and new synthesis of pyrrolo[1,2-b]pyridazine derivatives
title_sort expedient and new synthesis of pyrrolo[1,2-b]pyridazine derivatives
publisher Beilstein-Institut
series Beilstein Journal of Organic Chemistry
issn 1860-5397
publishDate 2009-11-01
description The reaction of 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide with tertiary butyl carbazate and subsequent condensation of the resulting carbamate derivative with a chalcone provided a facile new approach to pyrrolo[1,2-b]pyridazine derivatives.
topic 1,4-diketone
migration and cyclization
pyrrolo[1,2-b]pyridazine
tertiary butyl carbamate
tertiary butyl carbazate
α,β-unsaturated ketone
url https://doi.org/10.3762/bjoc.5.66
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