Hybrid Minigene Assay: An Efficient Tool to Characterize mRNA Splicing Profiles of <i>NF1</i> Variants

Hybrid Minigene Assay: An Efficient Tool to Characterize mRNA Splicing Profiles of <i>NF1</i> Variants

Neurofibromatosis type 1 (NF1) is caused by heterozygous loss of function mutations in the <i>NF1</i> gene. Although patients are diagnosed according to clinical criteria and few genotype-phenotype correlations are known, molecular analysis remains important. <i>NF1</i> displ...

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Bibliographic Details
Main Authors: Valeria Morbidoni, Elisa Baschiera, Monica Forzan, Valentina Fumini, Dario Seif Ali, Gianpietro Giorgi, Lisa Buson, Maria Andrea Desbats, Matteo Cassina, Maurizio Clementi, Leonardo Salviati, Eva Trevisson
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
neurofibromatosis type 1
<i>NF1</i>
splicing
minigene
hypomorphic
leaky splicing
Online Access:https://www.mdpi.com/2072-6694/13/5/999

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https://www.mdpi.com/2072-6694/13/5/999

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