Effects of oral zinc sulfate on hyperbilirubinemia in low-birth-weight neonates

Background: Hyperbilirubinemia is one of the most common and persistent problems encountered in preterm newborns. This condition in preterm infant is more likely to be associated with neurological damage rather than terms. So far, no major studies have precisely assessed the effects of zinc sulfate...

Full description

Bibliographic Details
Main Authors:	Ashraf Mohammadzadeh, Ahmadshah Farhat, Ahmad Ghasemian, Mohammad Ramezani, Habibullah Esmaily, Bibi Marziyeh Musavi
Format:	Article
Language:	English
Published:	Mashhad University of Medical Sciences 2016-06-01
Series:	Iranian Journal of Neonatology
Subjects:	Hyperbilirubinemia, LBW, Neonate, Zinc Sulfate1. Stoll BJ, Kliegman RM. Jaundice and hyperbilirubinemia in the newborn. In: Kliegman RM, Stanton B, Geme JS, Schor NF, Behrman RE, editors. Nelson Textbook of Pediatrics. 17th ed. Philadelphia: WB Saunders 1. Stoll BJ, Kliegman RM. Jaundice and hyperbilirubinemia in the newborn. In: Kliegman RM, Stanton B, Geme JS, Schor NF, Behrman RE, editors. Nelson Textbook of Pediatrics. 17th ed. Philadelphia: WB Saunders 2004. P. 562-96 2. Boskabadi H, Maamouri G, Mafinejad S. The effect of traditional remedies (Camel's Thorn, Flixweed and Sugar Water) on idiopathic neonatal jaundice. Iran J Pediatr. 2011 21(3):325-30 3. Boskabadi H, Maamouri G, Mafinejad S, Rezagholizadeh F. Clinical course and prognosis of hemolytic jaundice in neonates in north east of Iran. Maced J Med Sci. 2011 4(4):403-7 4. Maisels MJ, Pathak A, Nelson NM, Nathan DG, Smith CA. Endogenous production of carbon monoxide in normal and erythroblastotic newborn infants. J Clin Invest. 1971 50(1):1-8 5. Ambalavarna N, Carlo WA. Jaundice and hyperbilirubinemia. In: Kliegman RM, Stanton B, Geme JS, Schor NF, Behrman RE, editors. Nelson Textbook of Pediatrics. 19th ed. Philadelphia: WB Saunders 2011. P. 603-12 6. Kaplan M, Wong RJ, Sibley E, Stevenson DK. Neonatal jaundice and liver disease. In: Martin RJ, Fanaroff AA, Walsh MC, editors. Fanaroff and Martin's Neonatal-Perinatal Medicine. 9th ed. Amsterdam: Elsevier /Mosby 2011. P. 1443-96 7. Jahnson LH, Brown AK, Bhutani VK. System-based approach to management of neonatal jaundice and prevention of kernicterus. J Pediatr. 2002 140(4):396-403 8. Maisels MJ. Jaundice. In: MacDonald MG, Seshia MM, Mullett MD, editors. Avery’s Neonatology: Pathophysiology and Management of the Newborn. 6th ed. Philadelphia: Lippincott Williams & Wilkins 2005. P. 768-846 9. Kawade N, Onishi S. The prenatal and postnatal development of UDP-glucuronyltransferase activity toward bilirubin and the effect of premature birth on this activity in the human liver. Biochem J. 1981 196(1):257-60 10. Martin RJ, Fanaroff AA, Walsh MC. Fanaroff and Martin's neonatal-perinatal medicine: diseases of the fetus and infant. New York: Elsevier Health Sciences. 10th ed. 2015 P.1621-23 11. Méndez-Sánchez N, Roldán-Valadez E, Flores MA, Cárdenas-Vázquez R, Uribe M. Zinc salts precipitate unconjugated bilirubin in vitro and inhibit enterohepatic cycling of bilirubin in hamsters. Eur J Clin Invest. 2001 31(9):773-80 12. Mendez-Sanchez N, Martinez M, Gonzalez V, Roldan-Valadez E, Flores MA, Uribe M. Zinc sulfate inhibits the enterohepatic cycling of unconjugated bilirubin in subjects with Gilbert's syndrome. Ann Hepatol. 2002 1(1):40-3 13. Maisels MJ, Ostrea EM Jr, Touch S, Clune SE, Cepeda E, Kring E, et al. Evaluation of a new transcutaneous bilirubinometer. Pediatric. 2004 113(6):1628-35 14. Lathe GH, Ruthven CR. Factors affecting the rate of coupling of bilirubin and conjugated bilirubin in the van de Bergh reaction. J Clin Pathol. 1958 11(2):155-61 15. Martin RJ, Fanaroff AA, Walsh MC. Fanaroff and Martin's neonatal-perinatal medicine: diseases of the fetus and infant. 9th ed. New York: Elsevier Health Sciences 2011. P. 1476 16. Mohammadzade A, Farhat AS, Amiri R, Esmaely H, Bagheri S. Treatment effect of clofibrate in jaundiced low birth weight neonates. Int J Hematol Oncol. 2009 19(2):100-5 17. Rana N, Mishra S, Bhatnagar S, Paul V, Deorari AK, Agarwal R. Efficacy of zinc in reducing hyperbilirubinemia among at-risk neonates: a randomized, double-blind, placebo-controlled trial. Indian J Pediatr. 2011 78(9):1073-8 18. Mohammadzadeh A, Khorakian F, Ramezani M. Prophylactic effect of zinc sulfate on hyperbilirubinemia in premature very low birth weight neonates: a randomized clinical trial. Iran J Neonatol. 2015 5(4):6-10 19. Maamouri G, Boskabadi H, Mafinejad S, Bozorgnia Y, Khakshur A. Efficacy of oral zinc sulfate intake in prevention of neonatal jaundice. Iran J Neonatol. 2013 4(4):11-6 20. Patton DR, Sukadi A. Effect of oral zinc on hyperbilirubinemia in full term neonates. Paediatr Indones. 2011 51(2):107-10 21. Strand TA, Chandyo RK, Bahl R, Sharma PR, Adhikari RK, Bhandari N, et al. Effectiveness and efficacy of zinc for the treatment of acute diarrhea in young children. Pediatrics. 2002 109(5):898–903 22. Bahl R, Bhandari N, Saksena M, Strand T, Kumar GT, Bhan MK, et al. Efficacy of zinc fortified oral rehydration solution in 6- to 35-month-old children with acute diarrhea. J Pediatr. 2002 141(5):677–82 23. Fischer C, Harvey P. Low risks of adverse effects from zinc supplementation. Arlington: The USAID Micronutrient Program 2005
Online Access:	http://ijn.mums.ac.ir/article_7107_02600b3def0bb821be8318c42f2499b5.pdf