Mechanical stress-induced cell death in breast cancer cells

Providing an external mechanical stress to cancer cells seems to be an effective approach to treat cancer locally. Numbers of reports on cancer cell death subjected to mechanical stress loading are increasing, but they are more focused on apoptosis. Inducing necrosis is also important in attracting...

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Bibliographic Details
Main Authors:	Satomi Takao, Minoru Taya, Cerwyn Chiew
Format:	Article
Language:	English
Published:	The Company of Biologists 2019-08-01
Series:	Biology Open
Subjects:	Oscillating compression stress Breast cancer cells Apoptosis Necrosis Mechanical stress-induced cell death (MSICD)
Online Access:	http://bio.biologists.org/content/8/8/bio043133

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record_format	Article
spelling	doaj-34e2fc849ff840eca8bd069aec86cef12021-06-02T17:33:32ZengThe Company of BiologistsBiology Open2046-63902019-08-018810.1242/bio.043133043133Mechanical stress-induced cell death in breast cancer cellsSatomi Takao0Minoru Taya1Cerwyn Chiew2 Department of Mechanical Engineering, University of Washington, Seattle, WA 98195, USA Department of Mechanical Engineering, University of Washington, Seattle, WA 98195, USA Department of Mechanical Engineering, University of Washington, Seattle, WA 98195, USA Providing an external mechanical stress to cancer cells seems to be an effective approach to treat cancer locally. Numbers of reports on cancer cell death subjected to mechanical stress loading are increasing, but they are more focused on apoptosis. Inducing necrosis is also important in attracting more immune cells to the cancer site via the release of danger-associated molecular patterns from cancer cells. Here we applied dynamic compression to breast cancer cells with a low frequency (0.1–30 Hz) and for a short duration (30–300 s) and they resulted in a mixed mode of apoptosis and necrosis dominant with necrotic cell death, which we call mechanical stress-induced cell death (MSICD). The necrotic cell damage of mechanically treated breast cancer cells increased in a force-dependent and time-dependent manner while a trend of frequency-independent MSICD was observed.http://bio.biologists.org/content/8/8/bio043133Oscillating compression stressBreast cancer cellsApoptosisNecrosisMechanical stress-induced cell death (MSICD)
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Satomi Takao Minoru Taya Cerwyn Chiew
spellingShingle	Satomi Takao Minoru Taya Cerwyn Chiew Mechanical stress-induced cell death in breast cancer cells Biology Open Oscillating compression stress Breast cancer cells Apoptosis Necrosis Mechanical stress-induced cell death (MSICD)
author_facet	Satomi Takao Minoru Taya Cerwyn Chiew
author_sort	Satomi Takao
title	Mechanical stress-induced cell death in breast cancer cells
title_short	Mechanical stress-induced cell death in breast cancer cells
title_full	Mechanical stress-induced cell death in breast cancer cells
title_fullStr	Mechanical stress-induced cell death in breast cancer cells
title_full_unstemmed	Mechanical stress-induced cell death in breast cancer cells
title_sort	mechanical stress-induced cell death in breast cancer cells
publisher	The Company of Biologists
series	Biology Open
issn	2046-6390
publishDate	2019-08-01
description	Providing an external mechanical stress to cancer cells seems to be an effective approach to treat cancer locally. Numbers of reports on cancer cell death subjected to mechanical stress loading are increasing, but they are more focused on apoptosis. Inducing necrosis is also important in attracting more immune cells to the cancer site via the release of danger-associated molecular patterns from cancer cells. Here we applied dynamic compression to breast cancer cells with a low frequency (0.1–30 Hz) and for a short duration (30–300 s) and they resulted in a mixed mode of apoptosis and necrosis dominant with necrotic cell death, which we call mechanical stress-induced cell death (MSICD). The necrotic cell damage of mechanically treated breast cancer cells increased in a force-dependent and time-dependent manner while a trend of frequency-independent MSICD was observed.
topic	Oscillating compression stress Breast cancer cells Apoptosis Necrosis Mechanical stress-induced cell death (MSICD)
url	http://bio.biologists.org/content/8/8/bio043133
work_keys_str_mv	AT satomitakao mechanicalstressinducedcelldeathinbreastcancercells AT minorutaya mechanicalstressinducedcelldeathinbreastcancercells AT cerwynchiew mechanicalstressinducedcelldeathinbreastcancercells
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Mechanical stress-induced cell death in breast cancer cells

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