New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca<sup>2+</sup>-Modulating Activity Isolated from Sea Urchin Eggs

New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca<sup>2+</sup>-Modulating Activity Isolated from Sea Urchin Eggs

Herein, we report on the synthesis of a small set of linear precursors of an inosine analogue of cyclic ADP-ribose (cADPR), a second messenger involved in Ca<sup>2+</sup> mobilization from ryanodine receptor stores firstly isolated from sea urchin eggs extracts. The synthesized compounds...

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Bibliographic Details
Main Authors: Stefano D’Errico, Emy Basso, Andrea Patrizia Falanga, Maria Marzano, Tullio Pozzan, Vincenzo Piccialli, Gennaro Piccialli, Giorgia Oliviero, Nicola Borbone
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Marine Drugs
Subjects:
cADPR
ryanodine receptors
neuroblastoma
caffeine
calcium mobilization
phosphorylation
C2C12 cells
IP3
Online Access:https://www.mdpi.com/1660-3397/17/8/476

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