Loss of the cytoskeletal protein Pdlim7 predisposes mice to heart defects and hemostatic dysfunction.

Loss of the cytoskeletal protein Pdlim7 predisposes mice to heart defects and hemostatic dysfunction.

The actin-associated protein Pdlim7 is essential for heart and fin development in zebrafish; however, the expression and function of this PDZ-LIM family member in the mammal has remained unclear. Here, we show that Pdlim7 predominantly localizes to actin-rich structures in mice including the heart,...

Full description

Bibliographic Details
Main Authors: Jennifer Krcmery, Rajesh Gupta, Rudyard W Sadleir, Molly J Ahrens, Sol Misener, Christine Kamide, Philip Fitchev, Douglas W Losordo, Susan E Crawford, Hans-Georg Simon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3835322?pdf=render

Internet

http://europepmc.org/articles/PMC3835322?pdf=render

Similar Items