Vitamin C and Turmeric Attenuate Bax and Bcl-2 Proteins’ Expressions and DNA Damage in Lead Acetate-Induced Liver Injury

Vitamin C and Turmeric Attenuate Bax and Bcl-2 Proteins’ Expressions and DNA Damage in Lead Acetate-Induced Liver Injury

Background: Lead is a common environmental and occupational pollutant which induced multiorgans dysfunction. The present study was designed to investigate the hepatoprotective effects of turmeric (TUR) and/or vitamin C (Vit-C) alone or together against lead acetate toxicity and to explore novel mole...

Full description

Bibliographic Details
Main Authors:	Ahlam M. Alhusaini, Laila M. Faddah, Iman H. Hasan, Somayah J. Jarallah, Shrouq H. Alghamdi, Norah M. Alhadab, Amira Badr, Najlaa Elorabi, Enas Zakaria, Abeer Al-anazi
Format:	Article
Language:	English
Published:	SAGE Publishing 2019-11-01
Series:	Dose-Response
Online Access:	https://doi.org/10.1177/1559325819885782

Similar Items

Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: are we ready for Bcl-2-directed therapy?
by: Kulsoom B, et al.
Published: (2018-03-01)

Bcl-XL inhibits membrane permeabilization by competing with Bax.
by: Lieven P Billen, et al.
Published: (2008-06-01)

Role of Some Natural Antioxidants in the Modulation of Some Proteins Expressions against Sodium Fluoride-Induced Renal Injury
by: Ahlam M. Alhusaini, et al.
Published: (2018-01-01)

Expressão das proteínas BCL-2 e BAX em tumores astrocíticos humanos Expression of BCL-2 and BAX proteins in human astrocytic tumors
by: Mário Henrique Girão Faria, et al.
Published: (2006-08-01)

Cross Talk Between TGF-β and JAK Expressions and Nepherotoxicity Induced by Tetrachloromethane: Role of Phytotherapy
by: Laila M. Fadda, et al.
Published: (2019-08-01)

Lipopolysaccharide-induced dental pulp cell apoptosis and the expression of Bax and Bcl-2 in vitro
by: H. Yang, et al.
Published: (2010-11-01)

Expression of Bcl-2 and Bax in Advanced or Metastatic Prostate Carcinoma
by: Abdolazim Sedighi Pashak, et al.
Published: (2012-03-01)

Expressions of Bcl-2, Bax and Ki67 in the primary pterygium
by: Juan Li, et al.
Published: (2018-05-01)

Effect of doxorubicin on Bcl2 and Bax expression in Rat heart
by: Mohammadi Gorji S, et al.
Published: (2013-04-01)

The role of Bcl-2 and bax protein expression on individual radiosensitivity
by: Sogwagwa, Nkosikho
Published: (2017)

Association of Bax expression and Bcl2/Bax ratio with clinical and molecular prognostic markers in chronic lymphocytic leukemia
by: Vučićević Ksenija, et al.
Published: (2016-01-01)

Prophylactic Administration of Nanocurcumin Abates the Incidence of Liver Toxicity Induced by an Overdose of Copper Sulfate: Role of CYP4502E1, NF-κB and Bax Expressions
by: Ahlam Alhusaini, et al.
Published: (2018-12-01)

Curcumin Ameliorates Lead-Induced Hepatotoxicity by Suppressing Oxidative Stress and Inflammation, and Modulating Akt/GSK-3β Signaling Pathway
by: Ahlam Alhusaini, et al.
Published: (2019-11-01)

Opposite role of Bax and BCL-2 in the anti-tumoral responses of the immune system
by: Bougras Gwenola, et al.
Published: (2004-08-01)

GDNF Protects against Aluminum-Induced Apoptosis in Rabbits by Upregulating Bcl-2 and Bcl-XL and Inhibiting Mitochondrial Bax Translocation
by: Othman Ghribi, et al.
Published: (2001-10-01)

Effect of Frequency Aerobic Exercise on Expression of Bcl-2 and Bax Gene in Mice With Myocardial Infarction
by: M Ghahremani, et al.
Published: (2018-02-01)

The role of Bcl-2 protein, Bax protein and there ratio in peripheral blood lymphocytes of asthmatic patients
by: Israa F. Jaffar, et al.
Published: (2008-07-01)

Expression of Bcl-2 and Bax in mouse renal tubules during kidney development.
by: Xiao-Feng Song, et al.
Published: (2012-01-01)

p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell lymphoma.
by: Ningli Cheng, et al.
Published: (2008-04-01)

Bax/Bcl-2 expression ratio in prediction of response to breast cancer radiotherapy
by: Hosein Azimian, et al.
Published: (2018-03-01)

Retinal morphology and expression of Bcl-2, Bax and VEGF in early diabetic rats
by: Li-Jun Song, et al.
Published: (2018-11-01)

bcl-2、bax gene expression in oral carcinoma and the correlation with clinical prognosis
by: Yu-hsing Lin, et al.
Published: (2010)

The effects of melatonin and vitamin D3 on the gene expression of BCl-2 and BAX in MCF-7 breast cancer cell line
by: Abir A. Alamro, et al.
Published: (2021-03-01)

Apoptosis and cell cycle aberrations in epithelial odontogenic lesions: An evidence by the expression of p53, Bcl-2 and Bax
by: De Oliveira, D.-H.-I.-P, et al.
Published: (2018)

Thymoquinone Rescues T Lymphocytes from Gamma Irradiation-Induced Apoptosis and Exhaustion by Modulating Pro-Inflammatory Cytokine Levels and PD-1, Bax, and Bcl-2 Signaling
by: Mona Samy Guida, et al.
Published: (2016-02-01)

Wheat germ and vitamin E decrease BAX/BCL-2 ratio in rat kidney treated with gentamicin
by: Mohamed A.M. Kandeil, et al.
Published: (2018-09-01)

Ginger ameliorates reproductive toxicity of formaldehyde in male mice: Evidences for Bcl-2 and Bax
by: Ali Soleimanzadeh, et al.
Published: (2018-10-01)

Lobaplatin Inhibits Prostate Cancer Proliferation and Migration Through Regulation of BCL2 and BAX
by: Hongwen Cao, et al.
Published: (2019-06-01)

Correlation study of GAPDH, Bcl-2, and Bax protein immunoexpression in patients with colorectal adenocarcinoma
by: Marlena Brzozowa-Zasada, et al.
Published: (2018-12-01)

Expression of Bcl-2 and Bax genes in peripheral blood lymphocytes of depressed and nondepressed individuals
by: Meisam Amidfar, et al.
Published: (2019-01-01)

Effect of Interval and Continued Exercises with Crocin on Bax/Bcl-2 in Diabetic Obese Rats
by: Ghobad Hassanpour, et al.
Published: (2019-09-01)

Effects of Guanfu total base on Bcl-2 and Bax expression and correlation with atrial fibrillation
by: Yan Li, et al.
Published: (2018-09-01)

Bax mitochondrial relocation is linked to its phosphorylation and its interaction with Bcl-xL
by: David Garenne, et al.
Published: (2016-12-01)

Expression of the progesterone receptor, bcl-2 and bax in clomiphene citrate treated rat uteri
by: Dix-Peek, Therese
Published: (2011)

Regulation of apoptosis through bcl-2/bax proteins expression and DNA damage by nano-sized gadolinium oxide
by: Alarifi S, et al.
Published: (2017-06-01)

The Effect of Vitamin C on Apoptosis and Bax/Bcl-2 Proteins Ratio in Peripheral Blood Lymphocytes of Patients during Cardiac Interventional Procedures
by: H Nematollahi, et al.
Published: (2020-08-01)

Immunohistochemical expression of p53, BCL-2, BAX and VEGFR1 proteins in nephroblastomas A expressão imuno-histoquímica das proteínas p53, BCL-2, BAX e VEGFR1 em nefroblastomas
by: Ana Paula Percicote, et al.
Published: (2013-02-01)

Effect of N-acetyl cysteine on oxidative stress and Bax and Bcl2 expression in the kidney tissue of rats exposed to lead
by: M. Gholami, et al.
Published: (2021-02-01)

Apoptosis and the activity of ceramide, Bax and Bcl-2 in the lungs of neonatal rats exposed to limited and prolonged hyperoxia
by: Bitar Fadi F, et al.
Published: (2006-07-01)

Effect of Ascorbic Acid on Signaling Pathways of Bcl2 and Bax Genes in AGS Cell Line
by: yaser Asefi, et al.
Published: (2020-01-01)