SIRT1 gene polymorphisms associated with carcass traits in Luxi cattle

SIRT1 is the gene that codes for Sirtuin 1, an NAD (nicotinamide adenine dinucleotide)-dependent class III histone deacetylase. This gene plays a key role in adipose tissue and muscle development in animals. Chinese Luxi cattle (n  =  169) were selected to ident...

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Main Authors:	G. Liu, H. Zhao, X. Tan, H. Cheng, W. You, F. Wan, Y. Liu, E. Song, X. Liu
Format:	Article
Language:	English
Published:	Copernicus Publications 2017-03-01
Series:	Archives Animal Breeding
Online Access:	http://www.arch-anim-breed.net/60/27/2017/aab-60-27-2017.pdf

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spelling	doaj-34c5790917a046c5ba7125cdbd6284532020-11-25T01:08:42ZengCopernicus PublicationsArchives Animal Breeding0003-94382363-98222017-03-01601273210.5194/aab-60-27-2017<i>SIRT1</i> gene polymorphisms associated with carcass traits in Luxi cattleG. Liu0H. Zhao1X. Tan2H. Cheng3W. You4F. Wan5Y. Liu6E. Song7X. Liu8Shandong Key Lab of Animal Disease Control and Breeding, Sangyuan Road 8 Number, Ji'nan City, Shandong Province, 250100, ChinaShandong Key Lab of Animal Disease Control and Breeding, Sangyuan Road 8 Number, Ji'nan City, Shandong Province, 250100, ChinaShandong Key Lab of Animal Disease Control and Breeding, Sangyuan Road 8 Number, Ji'nan City, Shandong Province, 250100, ChinaShandong Key Lab of Animal Disease Control and Breeding, Sangyuan Road 8 Number, Ji'nan City, Shandong Province, 250100, ChinaShandong Key Lab of Animal Disease Control and Breeding, Sangyuan Road 8 Number, Ji'nan City, Shandong Province, 250100, ChinaShandong Key Lab of Animal Disease Control and Breeding, Sangyuan Road 8 Number, Ji'nan City, Shandong Province, 250100, ChinaShandong Key Lab of Animal Disease Control and Breeding, Sangyuan Road 8 Number, Ji'nan City, Shandong Province, 250100, ChinaShandong Key Lab of Animal Disease Control and Breeding, Sangyuan Road 8 Number, Ji'nan City, Shandong Province, 250100, ChinaShandong Key Lab of Animal Disease Control and Breeding, Sangyuan Road 8 Number, Ji'nan City, Shandong Province, 250100, China<i>SIRT1</i> is the gene that codes for Sirtuin 1, an NAD (nicotinamide adenine dinucleotide)-dependent class III histone deacetylase. This gene plays a key role in adipose tissue and muscle development in animals. Chinese Luxi cattle (<i>n</i>  =  169) were selected to identify <i>SIRT1</i> SNPs (single nucleotide polymorphisms) and investigate the relationship of these SNPs with carcass traits. Five SNPs (g.-382G  >  A, g.-274C  >  G, g.17324T  >  C, g.17379A  >  G, and g.17491G  >  A) were identified by direct sequencing. SNPs g.-382G  >  A and g.-274C  >  G were located within the promoter region of this gene. SNP g.-382G  >  A was significantly associated with dressing percentage, meat percentage, and striploin and ribeye weights, and the g.-274C  >  G polymorphism had a strong effect on carcass, tenderloin, and high rib weights in Luxi cattle. These findings will provide possible clues for the biological roles of <i>SIRT1</i> underlying beef cattle carcass traits.http://www.arch-anim-breed.net/60/27/2017/aab-60-27-2017.pdf
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	G. Liu H. Zhao X. Tan H. Cheng W. You F. Wan Y. Liu E. Song X. Liu
spellingShingle	G. Liu H. Zhao X. Tan H. Cheng W. You F. Wan Y. Liu E. Song X. Liu <i>SIRT1</i> gene polymorphisms associated with carcass traits in Luxi cattle Archives Animal Breeding
author_facet	G. Liu H. Zhao X. Tan H. Cheng W. You F. Wan Y. Liu E. Song X. Liu
author_sort	G. Liu
title	<i>SIRT1</i> gene polymorphisms associated with carcass traits in Luxi cattle
title_short	<i>SIRT1</i> gene polymorphisms associated with carcass traits in Luxi cattle
title_full	<i>SIRT1</i> gene polymorphisms associated with carcass traits in Luxi cattle
title_fullStr	<i>SIRT1</i> gene polymorphisms associated with carcass traits in Luxi cattle
title_full_unstemmed	<i>SIRT1</i> gene polymorphisms associated with carcass traits in Luxi cattle
title_sort	<i>sirt1</i> gene polymorphisms associated with carcass traits in luxi cattle
publisher	Copernicus Publications
series	Archives Animal Breeding
issn	0003-9438 2363-9822
publishDate	2017-03-01
description	<i>SIRT1</i> is the gene that codes for Sirtuin 1, an NAD (nicotinamide adenine dinucleotide)-dependent class III histone deacetylase. This gene plays a key role in adipose tissue and muscle development in animals. Chinese Luxi cattle (<i>n</i>  =  169) were selected to identify <i>SIRT1</i> SNPs (single nucleotide polymorphisms) and investigate the relationship of these SNPs with carcass traits. Five SNPs (g.-382G  >  A, g.-274C  >  G, g.17324T  >  C, g.17379A  >  G, and g.17491G  >  A) were identified by direct sequencing. SNPs g.-382G  >  A and g.-274C  >  G were located within the promoter region of this gene. SNP g.-382G  >  A was significantly associated with dressing percentage, meat percentage, and striploin and ribeye weights, and the g.-274C  >  G polymorphism had a strong effect on carcass, tenderloin, and high rib weights in Luxi cattle. These findings will provide possible clues for the biological roles of <i>SIRT1</i> underlying beef cattle carcass traits.
url	http://www.arch-anim-breed.net/60/27/2017/aab-60-27-2017.pdf
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<i>SIRT1</i> gene polymorphisms associated with carcass traits in Luxi cattle

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