Glial overexpression of Dube3a causes seizures and synaptic impairments in Drosophila concomitant with down regulation of the Na+/K+ pump ATPα

Glial overexpression of Dube3a causes seizures and synaptic impairments in Drosophila concomitant with down regulation of the Na+/K+ pump ATPα

Duplication 15q syndrome (Dup15q) is an autism-associated disorder co-incident with high rates of pediatric epilepsy. Additional copies of the E3 ubiquitin ligase UBE3A are thought to cause Dup15q phenotypes, yet models overexpressing UBE3A in neurons have not recapitulated the epilepsy phenotype. W...

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Bibliographic Details
Main Authors: Kevin A. Hope, Mark S. LeDoux, Lawrence T. Reiter
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Neurobiology of Disease
Subjects:
Duplication 15q syndrome
Seizure
Epilepsy
UBE3A
Dube3a
ATPα
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117302139

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