The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease

The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease

Abstract Objective Compromised brain cholesterol turnover and altered regulation of brain cholesterol metabolism have been allied with some neurodegenerative diseases, including Huntington’s disease (HD). Following our previous studies in HD, in this study we aim to investigate in vitro in a neurobl...

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Bibliographic Details
Main Authors: Clévio Nóbrega, André Conceição, Rafael G. Costa, Rebekah Koppenol, Raquel L. Sequeira, Ricardo Nunes, Sara Carmo-Silva, Adriana Marcelo, Carlos A. Matos, Sandrine Betuing, Jocelyne Caboche, Nathalie Cartier, Sandro Alves
Format: Article
Language:English
Published: BMC 2020-04-01
Series:BMC Research Notes
Subjects:
CYP46A1
Cholesterol
Neuroblastoma cells
Huntingtin
Autophagy
Online Access:http://link.springer.com/article/10.1186/s13104-020-05053-x

Internet

http://link.springer.com/article/10.1186/s13104-020-05053-x

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