Correlation Between Parathyroid Hormone Levels with Urinary Magnesium Excretion in Patients with Non-Dialysis Dependent Chronic Kidney Disease

• Main Authors: Carneiro Dias RS, José de Araújo Brito D, Milhomem dos Santos E, Cadilhe de Oliveira Costa R, Martins Melo Fontenele A, Viana Hortegal Furtado E, Santos Lages J, Miranda dos Santos A, Freitas Santos EJ, de Lima Carneiro ECR, Cruz Diniz MC, Barbosa CDT, Costa de Sales Muniz A, Teixeira da Cunha França AK, Salgado Filho N, Vianna Araújo D, Bernardo-Filho M
• Format: Article
• Language: English
• Published: Dove Medical Press 2020-11-01
• Series: International Journal of Nephrology and Renovascular Disease
• Subjects: magnesium. parathyroid hormone. kidney diseases.
• Online Access: https://www.dovepress.com/correlation-between-parathyroid-hormone-levels-with-urinary-magnesium--peer-reviewed-article-IJNRD

Raimunda Sheyla Carneiro Dias,1 Dyego José de Araújo Brito,1 Elisângela Milhomem dos Santos,2 Rayanna Cadilhe de Oliveira Costa,1 Andrea Martins Melo Fontenele,1 Elane Viana Hortegal Furtado,1 Joyce Santos Lages,1 Alcione Miranda dos Santos,3 Elton Jonh Freitas Santos,1 Érika Cristina Ribeiro de Lima Carneiro,1 Maria Célia Cruz Diniz,1 Carla Déa Trindade Barbosa,1 Alessandra Costa de Sales Muniz,1 Ana Karina Teixeira da Cunha França,3 Natalino Salgado Filho,4 Denizar Vianna Araújo,5 Mário Bernardo-Filho6 1Center for Prevention of Kidney Diseases, University Hospital of the Federal University of Maranhão, São Luís, MA, Brazil; 2Nursing Department, Federal University of Maranhão, São Luís, MA, Brazil; 3Public Health Department, Federal University of Maranhão, São Luís, MA, Brazil; 4Department of Medicine I, Federal University of Maranhão, São Luís, MA, Brazil; 5Department of Internal Medicine, University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil; 6Laboratory of Mechanical Vibrations and Integrative Practices, Department of Biophysics and Biometrics, Institute of Biology Roberto Alcântara Gomes and Polyclinic Américo Piquet Carneiro, University of the State of Rio de Janeiro, Rio de Janeiro, RJ, BrazilCorrespondence: Raimunda Sheyla Carneiro Dias Tel [phone]Email [e-mail]: Disorders of mineral metabolism occur in most patients with chronic kidney disease (CKD). The aim of this work was to correlate parathyroid hormone (PTH) levels with urinary magnesium excretion in patients with non-dialysis dependent CKD.Methods: Cross-sectional study. Concentrations of creatinine, magnesium, calcium, phosphate, parathyroid hormone (PTH), 25-hydroxyvitamin D [25(OH)D] and alkaline phosphatase (ALP) were determined in blood samples. The assessment of urinary magnesium levels was performed by means of total daily excretion and by the excretion fraction (FEMg).Results: The study evaluated 163 patients with a mean age of 60.7 ± 11.7 years and 51.0% were male. In the highest quartile of PTH (> 89.5pg/mL), the mean levels of FEMg and ALP were higher (p< 0.05). In the unadjusted regression analysis, the following variables were related to serum PTH levels: FEMg (odds ratio (OR) = 1.12; 95% confidence intervals (CI): 1.02– 1.23), calcium (OR = 0.45; 95% CI: 0.22– 0.90), ALP (OR = 1.02; 95% CI: 1.00– 1.03) and eGFR (OR = 0.92; 95% CI: 1.00– 1.03). After an adjusted analysis, only one FEMg and ALP will remain correlated with PTH.Conclusion: In patients with non-dialysis dependent CKD, FEMg and ALP were some variables that remained associated with PTH.Keywords: magnesium, parathyroid hormone, kidney diseases