Flow-Injection Amperometric Determination of Tacrine based on Ion Transfer across a Water–Plasticized Polymeric Membrane Interface

• Main Authors: C. Rueda, Joaquin A. Ortuño
• Format: Article
• Language: English
• Published: MDPI AG 2007-07-01
• Series: Sensors
• Subjects: Interface between Two Immiscible Electrolyte Solutions; ion amperometry; plasticized polymeric membrane; tacrine determination; flow-injection analysis
• Online Access: http://www.mdpi.com/1424-8220/7/7/1185/

A flow-injection pulse amperometric method for determining tacrine, based onion transfer across a plasticized poly(vinyl chloride) (PVC) membrane, was developed. Afour-electrode potentiostat with ohmic drop compensation was used, while a flow-throughcell incorporated the four electrodes and the membrane, which containedtetrabutylammonium tetraphenylborate. The influence of the applied potential and of theflow-injection variables on the determination of tacrine was studied. In the selectedconditions, a linear relationship between peak height and tacrine concentration was foundup to 4x10-5M tacrine. The detection limit was 1x10-7M. Good repeatability was obtained.Some common ions and pharmaceutical excipients did not interfere.