6-Bromo-<em>N</em>-(3-(Difluoromethyl)phenyl)quinolin-4-Amine

6-Bromo-<em>N</em>-(3-(Difluoromethyl)phenyl)quinolin-4-Amine

A routine synthesis was performed to furnish the title compound which incorporates a versatile difluoromethyl group on the aniline substitution of a 4-anilinoquinoline kinase inhibitor motif. In addition, the small molecule crystal structure (of the HCL salt) was solved, which uncovered that the dif...

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Bibliographic Details
Main Authors: Christopher R. M. Asquith, Graham J. Tizzard
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molbank
Subjects:
4-anilino-quin(az)olines
hinge binder
conformational flexibility
kinase inhibitor design
Online Access:https://www.mdpi.com/1422-8599/2020/4/M1161
Description
Summary:A routine synthesis was performed to furnish the title compound which incorporates a versatile difluoromethyl group on the aniline substitution of a 4-anilinoquinoline kinase inhibitor motif. In addition, the small molecule crystal structure (of the HCL salt) was solved, which uncovered that the difluoromethyl group was disordered within the packing arrangement and also a 126.08(7)° out of plane character between the respective ring systems within the molecule. The compound was fully characterized with <sup>1</sup>H/<sup>13</sup>C-NMR and high-resolution mass spectra (HRMS), with the procedures described.
ISSN:1422-8599

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