Carbamoylating activity associated with the activation of the antitumor agent laromustine inhibits angiogenesis by inducing ASK1-dependent endothelial cell death.

Carbamoylating activity associated with the activation of the antitumor agent laromustine inhibits angiogenesis by inducing ASK1-dependent endothelial cell death.

The anticancer agent 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (laromustine), upon decomposition in situ, yields methyl isocyanate and the chloroethylating species 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine (90CE). 90CE has been shown to kill tumor cells vi...

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Bibliographic Details
Main Authors: Weidong Ji, Mei Yang, Alexandra Praggastis, Yonghao Li, Huanjiao Jenny Zhou, Yun He, Roxanne Ghazvinian, Dylan J Cincotta, Kevin P Rice, Wang Min
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4113355?pdf=render

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http://europepmc.org/articles/PMC4113355?pdf=render

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