TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons

TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons

Midbrain dopamine (DA) neurons are slow pacemakers that maintain extracellular DA levels. During the interspike intervals, subthreshold slow depolarization underlies autonomous pacemaking and determines its rate. However, the ion channels that determine slow depolarization are unknown. Here we show...

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Bibliographic Details
Main Authors: Ki Bum Um, Suyun Hahn, So Woon Kim, Yoon Je Lee, Lutz Birnbaumer, Hyun Jin Kim, Myoung Kyu Park
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
dopaminergic neurons
substantia nigra
pacemaker channels
pacemaking
TRPC3
NALCN
Online Access:https://elifesciences.org/articles/70920

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