AIM2 Co-immunization with VP1 Is Associated with Increased Memory CD8 T Cells and Mounts Long Lasting Protection against Coxsackievirus B3 Challenge

AIM2 Co-immunization with VP1 Is Associated with Increased Memory CD8 T Cells and Mounts Long Lasting Protection against Coxsackievirus B3 Challenge

The recurrent Coxsackievirus B3 (CVB3) infection is the most important cause of intractable myocarditis which often leads to chronic myocarditis and even dilated cardiomyopathy. Therefore, enhanced DNA vaccines capable of memory CD8 T cells are essential for long-lasting immunological protection aga...

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Bibliographic Details
Main Authors: Liang Yin, Dafei Chai, Yan Yue, Chunsheng Dong, Sidong Xiong
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Coxsackievirus B3
viral myocarditis
DNA vaccine
adjuvant
AIM2
memory CD8 T cells
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00247/full

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