CpG and UpA dinucleotides in both coding and non-coding regions of echovirus 7 inhibit replication initiation post-entry

CpG and UpA dinucleotides in both coding and non-coding regions of echovirus 7 inhibit replication initiation post-entry

Most vertebrate and plant RNA and small DNA viruses suppress genomic CpG and UpA dinucleotide frequencies, apparently mimicking host mRNA composition. Artificially increasing CpG/UpA dinucleotides attenuates viruses through an entirely unknown mechanism. Using the echovirus 7 (E7) model in several c...

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Bibliographic Details
Main Authors: Jelke Jan Fros, Isabelle Dietrich, Kinda Alshaikhahmed, Tim Casper Passchier, David John Evans, Peter Simmonds
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
CpG
UpA
dinucleotides
codon bias
enterovirus
Online Access:https://elifesciences.org/articles/29112

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