Consistent B Cell Receptor Immunoglobulin Features Between Siblings in Familial Chronic Lymphocytic Leukemia

Consistent B Cell Receptor Immunoglobulin Features Between Siblings in Familial Chronic Lymphocytic Leukemia

Key processes in the onset and evolution of chronic lymphocytic leukemia (CLL) are thought to include chronic (antigenic) activation of mature B cells through the B cell receptor (BcR), signals from the microenvironment, and acquisition of genetic alterations. Here we describe three families in whic...

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Bibliographic Details
Main Authors: P. Martijn Kolijn, Alice F. Muggen, Viktor Ljungström, Andreas Agathangelidis, Ingrid L. M. Wolvers-Tettero, H. Berna Beverloo, Karol Pál, Paul J. Hengeveld, Nikos Darzentas, Rudi W. Hendriks, Jacques J. M. van Dongen, Richard Rosenquist, Anton W. Langerak
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
CLL (Chronic Lymphocytic Leukemia)
Familial CLL
BCR stereotypy
IGLV3-21 R110
CLL development
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.740083/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.740083/full

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