PRIMARY SJOGREN'S SYNDROME ASSOCIATED WITH ANTICENTROMERE ANTIBODIES
Anti-centromere antibody (ANCA) seropositivity is generally regarded by rheumatologists as a sign of systemic sclerosis (SS) in clinical practice. However, the literature describes many cases of ANCA-associated primary Sjogren's syndrome (PSS) that is the subtype of this disease, which differs...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2018-05-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2530 |
| Summary: | Anti-centromere antibody (ANCA) seropositivity is generally regarded by rheumatologists as a sign of systemic sclerosis (SS) in clinical practice. However, the literature describes many cases of ANCA-associated primary Sjogren's syndrome (PSS) that is the subtype of this disease, which differs from the classic type in a number of laboratory and clinical manifestations. According to the literature, even a long-term follow-up indicates that only one quarter of patients with ANCA-positive PSS develop documented SS. This fact raises the question of whether it is necessary to include ANCA into the list of autoantibodies pathogenetically related to PSS. |
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| ISSN: | 1995-4484 1995-4492 |