Mechanism of action of a nitroimidazole-thiadiazole derivate upon Trypanosoma cruzi tissue culture amastigotes

Mechanism of action of a nitroimidazole-thiadiazole derivate upon Trypanosoma cruzi tissue culture amastigotes

Megazol (CL 64,855) a very effective drug in experimental infections by Trypanosoma cruzi, and also in in vitro assays with vertebrate forms of the parasite, had its parasite, had its activity upon macromolecule biosynthesis tested using tissue culture-derived amastigote forms. Megazol presented a d...

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Bibliographic Details
Main Authors:	Solange L. de Castro, Maria de Nazareth L. Meirelles
Format:	Article
Language:	English
Published:	Instituto Oswaldo Cruz, Ministério da Saúde 1990-03-01
Series:	Memórias do Instituto Oswaldo Cruz.
Subjects:	Trypanosoma cruzi chemotherapeutic agents amastigotes macromolecule biosynthesis radiactive precursors action of thiadiazole derivate megazol
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761990000100016

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