Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix

Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix

Upregulation of voltage-gated sodium channels (VGSCs) and Na<sup>+</sup>/K<sup>+</sup>-ATPase (sodium pumps) is common across most malignant carcinomas. Targeted osmotic lysis (TOL) is a developing technology in which the concomitant stimulation of VGSCs and pharmacological b...

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Bibliographic Details
Main Authors: Harry J. Gould, Paige R. Miller, Samantha Edenfield, Kelly Jean Sherman, Chad K. Brady, Dennis Paul
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Current Oncology
Subjects:
targeted osmotic lysis
advanced-stage cervical cancer
sodium channels
sodium pumps
Online Access:https://www.mdpi.com/1718-7729/28/3/196
id doaj-34690d1de6b64c57b9ebf0d43ee732a4
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spelling doaj-34690d1de6b64c57b9ebf0d43ee732a42021-09-20T10:11:31ZengMDPI AGCurrent Oncology1198-00521718-77292021-06-01281962115212210.3390/curroncol28030196Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the CervixHarry J. Gould0Paige R. Miller1Samantha Edenfield2Kelly Jean Sherman3Chad K. Brady4Dennis Paul5Department of Neurology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USAOleander Medical Technologies, Baton Rouge, LA 70803, USADepartment of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USADepartment of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USADepartment of Radiology, West Virginia University Medical School, Morgantown, WV 26506, USAOleander Medical Technologies, Baton Rouge, LA 70803, USAUpregulation of voltage-gated sodium channels (VGSCs) and Na<sup>+</sup>/K<sup>+</sup>-ATPase (sodium pumps) is common across most malignant carcinomas. Targeted osmotic lysis (TOL) is a developing technology in which the concomitant stimulation of VGSCs and pharmacological blockade of sodium pumps causes rapid selective osmotic lysis of carcinoma cells. This treatment of cervical carcinoma is evidence that TOL is a safe, well-tolerated and effective treatment for aggressive advanced carcinomas that has the potential to extend life without compromising its quality. TOL is likely to have broad application for the treatment of advanced-stage carcinomas.https://www.mdpi.com/1718-7729/28/3/196targeted osmotic lysisadvanced-stage cervical cancersodium channelssodium pumps
collection DOAJ
language English
format Article
sources DOAJ
author Harry J. Gould
Paige R. Miller
Samantha Edenfield
Kelly Jean Sherman
Chad K. Brady
Dennis Paul
spellingShingle Harry J. Gould
Paige R. Miller
Samantha Edenfield
Kelly Jean Sherman
Chad K. Brady
Dennis Paul
Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix
Current Oncology
targeted osmotic lysis
advanced-stage cervical cancer
sodium channels
sodium pumps
author_facet Harry J. Gould
Paige R. Miller
Samantha Edenfield
Kelly Jean Sherman
Chad K. Brady
Dennis Paul
author_sort Harry J. Gould
title Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix
title_short Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix
title_full Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix
title_fullStr Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix
title_full_unstemmed Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix
title_sort emergency use of targeted osmotic lysis for the treatment of a patient with aggressive late-stage squamous cell carcinoma of the cervix
publisher MDPI AG
series Current Oncology
issn 1198-0052
1718-7729
publishDate 2021-06-01
description Upregulation of voltage-gated sodium channels (VGSCs) and Na<sup>+</sup>/K<sup>+</sup>-ATPase (sodium pumps) is common across most malignant carcinomas. Targeted osmotic lysis (TOL) is a developing technology in which the concomitant stimulation of VGSCs and pharmacological blockade of sodium pumps causes rapid selective osmotic lysis of carcinoma cells. This treatment of cervical carcinoma is evidence that TOL is a safe, well-tolerated and effective treatment for aggressive advanced carcinomas that has the potential to extend life without compromising its quality. TOL is likely to have broad application for the treatment of advanced-stage carcinomas.
topic targeted osmotic lysis
advanced-stage cervical cancer
sodium channels
sodium pumps
url https://www.mdpi.com/1718-7729/28/3/196
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AT paigermiller emergencyuseoftargetedosmoticlysisforthetreatmentofapatientwithaggressivelatestagesquamouscellcarcinomaofthecervix
AT samanthaedenfield emergencyuseoftargetedosmoticlysisforthetreatmentofapatientwithaggressivelatestagesquamouscellcarcinomaofthecervix
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