Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix

Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix

Upregulation of voltage-gated sodium channels (VGSCs) and Na<sup>+</sup>/K<sup>+</sup>-ATPase (sodium pumps) is common across most malignant carcinomas. Targeted osmotic lysis (TOL) is a developing technology in which the concomitant stimulation of VGSCs and pharmacological b...

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Bibliographic Details
Main Authors: Harry J. Gould, Paige R. Miller, Samantha Edenfield, Kelly Jean Sherman, Chad K. Brady, Dennis Paul
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Current Oncology
Subjects:
targeted osmotic lysis
advanced-stage cervical cancer
sodium channels
sodium pumps
Online Access:https://www.mdpi.com/1718-7729/28/3/196
Description
Summary:Upregulation of voltage-gated sodium channels (VGSCs) and Na<sup>+</sup>/K<sup>+</sup>-ATPase (sodium pumps) is common across most malignant carcinomas. Targeted osmotic lysis (TOL) is a developing technology in which the concomitant stimulation of VGSCs and pharmacological blockade of sodium pumps causes rapid selective osmotic lysis of carcinoma cells. This treatment of cervical carcinoma is evidence that TOL is a safe, well-tolerated and effective treatment for aggressive advanced carcinomas that has the potential to extend life without compromising its quality. TOL is likely to have broad application for the treatment of advanced-stage carcinomas.
ISSN:1198-0052
1718-7729

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