Prevalence of a Iodothyronine Deiodinase 2 gene single nucleotide polymorphism in children with congenital hypothyroidism from Western Romania and impact on TSH levels

Prevalence of a Iodothyronine Deiodinase 2 gene single nucleotide polymorphism in children with congenital hypothyroidism from Western Romania and impact on TSH levels

The aim of this study was to evaluate the prevalence of the Iodothyronine Deiodinase 2 gene Thr92Ala polymorphism in children from West of Romania with congenital hypothyroidism (CH) and association with TSH levels in response to levothyroxine monotherapy.

Bibliographic Details
Main Authors: Mang Niculina, Tămas Liviu Athos, Mărginean Otilia, Marian Cătălin, Ursoniu Sorin, Anghel Andrei
Format: Article
Language:English
Published: Sciendo 2019-04-01
Series:Romanian Journal of Laboratory Medicine
Subjects:
congenital hypothyroidism
deiodinase type 2
endocrine disorder
gene polymorphism
Online Access:https://doi.org/10.2478/rrlm-2019-0012
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spelling doaj-346609186ec04cbd9d7f397e48e747732021-09-05T14:01:31ZengSciendoRomanian Journal of Laboratory Medicine2284-56232019-04-0127216917810.2478/rrlm-2019-0012rrlm-2019-0012Prevalence of a Iodothyronine Deiodinase 2 gene single nucleotide polymorphism in children with congenital hypothyroidism from Western Romania and impact on TSH levelsMang Niculina0Tămas Liviu Athos1Mărginean Otilia2Marian Cătălin3Ursoniu Sorin4Anghel Andrei5Department of Pediatrics, “Victor Babes” University of Medicine and Pharmacy, Timisoara, RomaniaDepartment of Biochemistry and Pharmacology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, RomaniaDepartment of Pediatrics, “Victor Babes” University of Medicine and Pharmacy, Timisoara, RomaniaDepartment of Biochemistry and Pharmacology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, RomaniaDepartment of Public Health Medicine, “Victor Babes” University of Medicine and Pharmacy, Timisoara, RomaniaDepartment of Biochemistry and Pharmacology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, RomaniaThe aim of this study was to evaluate the prevalence of the Iodothyronine Deiodinase 2 gene Thr92Ala polymorphism in children from West of Romania with congenital hypothyroidism (CH) and association with TSH levels in response to levothyroxine monotherapy.https://doi.org/10.2478/rrlm-2019-0012congenital hypothyroidismdeiodinase type 2endocrine disordergene polymorphism
collection DOAJ
language English
format Article
sources DOAJ
author Mang Niculina
Tămas Liviu Athos
Mărginean Otilia
Marian Cătălin
Ursoniu Sorin
Anghel Andrei
spellingShingle Mang Niculina
Tămas Liviu Athos
Mărginean Otilia
Marian Cătălin
Ursoniu Sorin
Anghel Andrei
Prevalence of a Iodothyronine Deiodinase 2 gene single nucleotide polymorphism in children with congenital hypothyroidism from Western Romania and impact on TSH levels
Romanian Journal of Laboratory Medicine
congenital hypothyroidism
deiodinase type 2
endocrine disorder
gene polymorphism
author_facet Mang Niculina
Tămas Liviu Athos
Mărginean Otilia
Marian Cătălin
Ursoniu Sorin
Anghel Andrei
author_sort Mang Niculina
title Prevalence of a Iodothyronine Deiodinase 2 gene single nucleotide polymorphism in children with congenital hypothyroidism from Western Romania and impact on TSH levels
title_short Prevalence of a Iodothyronine Deiodinase 2 gene single nucleotide polymorphism in children with congenital hypothyroidism from Western Romania and impact on TSH levels
title_full Prevalence of a Iodothyronine Deiodinase 2 gene single nucleotide polymorphism in children with congenital hypothyroidism from Western Romania and impact on TSH levels
title_fullStr Prevalence of a Iodothyronine Deiodinase 2 gene single nucleotide polymorphism in children with congenital hypothyroidism from Western Romania and impact on TSH levels
title_full_unstemmed Prevalence of a Iodothyronine Deiodinase 2 gene single nucleotide polymorphism in children with congenital hypothyroidism from Western Romania and impact on TSH levels
title_sort prevalence of a iodothyronine deiodinase 2 gene single nucleotide polymorphism in children with congenital hypothyroidism from western romania and impact on tsh levels
publisher Sciendo
series Romanian Journal of Laboratory Medicine
issn 2284-5623
publishDate 2019-04-01
description The aim of this study was to evaluate the prevalence of the Iodothyronine Deiodinase 2 gene Thr92Ala polymorphism in children from West of Romania with congenital hypothyroidism (CH) and association with TSH levels in response to levothyroxine monotherapy.
topic congenital hypothyroidism
deiodinase type 2
endocrine disorder
gene polymorphism
url https://doi.org/10.2478/rrlm-2019-0012
work_keys_str_mv AT mangniculina prevalenceofaiodothyroninedeiodinase2genesinglenucleotidepolymorphisminchildrenwithcongenitalhypothyroidismfromwesternromaniaandimpactontshlevels
AT tamasliviuathos prevalenceofaiodothyroninedeiodinase2genesinglenucleotidepolymorphisminchildrenwithcongenitalhypothyroidismfromwesternromaniaandimpactontshlevels
AT margineanotilia prevalenceofaiodothyroninedeiodinase2genesinglenucleotidepolymorphisminchildrenwithcongenitalhypothyroidismfromwesternromaniaandimpactontshlevels
AT mariancatalin prevalenceofaiodothyroninedeiodinase2genesinglenucleotidepolymorphisminchildrenwithcongenitalhypothyroidismfromwesternromaniaandimpactontshlevels
AT ursoniusorin prevalenceofaiodothyroninedeiodinase2genesinglenucleotidepolymorphisminchildrenwithcongenitalhypothyroidismfromwesternromaniaandimpactontshlevels
AT anghelandrei prevalenceofaiodothyroninedeiodinase2genesinglenucleotidepolymorphisminchildrenwithcongenitalhypothyroidismfromwesternromaniaandimpactontshlevels
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