Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells

Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells

Protective T cell responses against tumors require the production of Interferon gamma (IFN-γ). However, tumor-infiltrating T cells (TILs) gradually lose their capacity to produce IFN-γ and therefore fail to clear malignant cells. Dissecting the underlying mechanisms that block cytokine production is...

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Bibliographic Details
Main Authors:	Fiamma Salerno, Aurelie Guislain, Julian J. Freen-Van Heeren, Benoit P. Nicolet, Howard A. Young, Monika C. Wolkers
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2019-02-01
Series:	OncoImmunology
Subjects:	tumor-infiltrating t cells ifn-γ mrna stability post-transcriptional regulation cd28 pd-1 b16 melanoma
Online Access:	http://dx.doi.org/10.1080/2162402X.2018.1532762

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