Influence of osmolality on gastrointestinal fluid volume and drug absorption: potential impact on oral salt supplementation

Influence of osmolality on gastrointestinal fluid volume and drug absorption: potential impact on oral salt supplementation

Abstract Background The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is the most frequent cause of hyponatremia in patients with cerebrovascular disease, and is often treated with oral salt tablets. However, we have shown that osmolality-dependent variations in gastrointestina...

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Bibliographic Details
Main Authors: Miyuki Takemura, Yuki Tanaka, Katsuhisa Inoue, Ikumi Tamai, Yoshiyuki Shirasaka
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
Drug absorption
Gastrointestinal tract
Pharmacokinetics
Osmolality
Membrane permeability
Online Access:https://doi.org/10.1186/s40780-021-00212-z

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