The INT6 cancer gene and MEK signaling pathways converge during zebrafish development.

The INT6 cancer gene and MEK signaling pathways converge during zebrafish development.

BACKGROUND:Int-6 (integration site 6) was identified as an oncogene in a screen of tumorigenic mouse mammary tumor virus (MMTV) insertions. INT6 expression is altered in human cancers, but the precise role of disrupted INT6 in tumorigenesis remains unclear, and an animal model to study Int-6 physiol...

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Bibliographic Details
Main Authors:	Michal Grzmil, Danny Whiting, John Maule, Corina Anastasaki, James F Amatruda, Robert N Kelsh, Chris J Norbury, E Elizabeth Patton
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2007-09-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC1978538?pdf=render

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