Kaempferide Protects against Myocardial Ischemia/Reperfusion Injury through Activation of the PI3K/Akt/GSK-3β Pathway

Kaempferide Protects against Myocardial Ischemia/Reperfusion Injury through Activation of the PI3K/Akt/GSK-3β Pathway

The aim of this study is to investigate both the efficacy and mechanism of action of kaempferide (Kae) as a therapy for the treatment of cardiovascular disease. A rat model of myocardial ischemia/reperfusion (I/R) injury was established by ligation of the left anterior descending coronary artery for...

Full description

Bibliographic Details
Main Authors:	Dong Wang, Xinjie Zhang, Defang Li, Wenjin Hao, Fanqing Meng, Bo Wang, Jichun Han, Qiusheng Zheng
Format:	Article
Language:	English
Published:	Hindawi Limited 2017-01-01
Series:	Mediators of Inflammation
Online Access:	http://dx.doi.org/10.1155/2017/5278218

Similar Items

Astaxanthin alleviates spinal cord ischemia-reperfusion injury via activation of PI3K/Akt/GSK-3β pathway in rats
by: Jian Fu, et al.
Published: (2020-07-01)

Ginsenoside Rd attenuates myocardial ischemia/reperfusion injury via Akt/GSK-3β signaling and inhibition of the mitochondria-dependent apoptotic pathway.
by: Yang Wang, et al.
Published: (2013-01-01)

Eriodictyol Attenuates Myocardial Ischemia-Reperfusion Injury through the Activation of JAK2
by: Defang Li, et al.
Published: (2018-01-01)

Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway
by: Y. Wang, et al.
Published: (2013-09-01)

Tetramethylpyrazine exerts a protective effect against injury from acute myocardial ischemia by regulating the PI3K/Akt/GSK-3β signaling pathway
by: Qing Yang, et al.
Published: (2019-02-01)

Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: Role of GSK-3β in Myocardial Protection Against Ischemia/Reperfusion Injury
by: Tetsuji Miura, et al.
Published: (2009-01-01)

Cardioprotective Effects of Astragalin against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart
by: Daoxu Qu, et al.
Published: (2016-01-01)

Catestatin exerts direct protective effects on rat cardiomyocytes undergoing ischemia/reperfusion by stimulating PI3K-Akt-GSK3β pathway and preserving mitochondrial membrane potential.
by: Eleonora Bassino, et al.
Published: (2015-01-01)

Troxerutin Protects Against Myocardial Ischemia/Reperfusion Injury Via Pi3k/Akt Pathway in Rats
by: Liliang Shu, et al.
Published: (2017-12-01)

6-Gingerol Activates PI3K/Akt and Inhibits Apoptosis to Attenuate Myocardial Ischemia/Reperfusion Injury
by: Xiangwei Lv, et al.
Published: (2018-01-01)

Hydroxytyrosol Protects against Myocardial Ischemia/Reperfusion Injury through a PI3K/Akt-Dependent Mechanism
by: Ying-hao Pei, et al.
Published: (2016-01-01)

DRD4 Mitigates Myocardial Ischemia/Reperfusion Injury in Association With PI3K/AKT Mediated Glucose Metabolism
by: Xue-song Liu, et al.
Published: (2021-01-01)

Rosmarinic Acid Protects against Inflammation and Cardiomyocyte Apoptosis during Myocardial Ischemia/Reperfusion Injury by Activating Peroxisome Proliferator-Activated Receptor Gamma
by: Jichun Han, et al.
Published: (2017-07-01)

Protective Effects of Kaempferol against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart via Antioxidant Activity and Inhibition of Glycogen Synthase Kinase-3β
by: Mingjie Zhou, et al.
Published: (2015-01-01)

Asiatic Acid Attenuates Myocardial Ischemia/Reperfusion Injury via Akt/GSK-3β/HIF-1α Signaling in Rat H9c2 Cardiomyocytes
by: Xiang Huang, et al.
Published: (2016-09-01)

Effects of Dexmedetomidine Postconditioning on Myocardial Ischemia/Reperfusion Injury in Diabetic Rats: Role of the PI3K/Akt-Dependent Signaling Pathway
by: Xiangyang Cheng, et al.
Published: (2018-01-01)

Carvacrol alleviates ischemia reperfusion injury by regulating the PI3K-Akt pathway in rats.
by: Lida Suo, et al.
Published: (2014-01-01)

The Role of Insulin/IGF-1/PI3K/Akt/GSK3β Signaling in Parkinson's Disease Dementia
by: Liying Yang, et al.
Published: (2018-02-01)

Hydrogen sulfide preconditioning protects rat liver against ischemia/reperfusion injury by activating Akt-GSK-3β signaling and inhibiting mitochondrial permeability transition.
by: Qingqing Zhang, et al.
Published: (2013-01-01)

Short-Term Hesperidin Pretreatment Attenuates Rat Myocardial Ischemia/Reperfusion Injury by Inhibiting High Mobility Group Box 1 Protein Expression via the PI3K/Akt Pathway
by: Xuefei Li, et al.
Published: (2016-10-01)

GSK3β inhibits epithelial-mesenchymal transition via the Wnt/β-catenin and PI3K/Akt pathways
by: Cheng Zhang, et al.
Published: (2018-07-01)

Clemastine Fumarate Protects Against Myocardial Ischemia Reperfusion Injury by Activating the TLR4/PI3K/Akt Signaling Pathway
by: Xiaoxiao Yuan, et al.
Published: (2020-02-01)

Bauhinia championii flavone inhibits apoptosis and autophagy via the PI3K/Akt pathway in myocardial ischemia/reperfusion injury in rats
by: Jian J, et al.
Published: (2015-11-01)

Lupeol Alleviates Cerebral Ischemia–Reperfusion Injury in Correlation with Modulation of PI3K/Akt Pathway
by: Wang Z, et al.
Published: (2020-06-01)

Neuroprotective Effects of Salicin in a Gerbil Model of Transient Forebrain Ischemia by Attenuating Oxidative Stress and Activating PI3K/Akt/GSK3β Pathway
by: Joon Ha Park, et al.
Published: (2021-04-01)

Dexamethasone induces osteoblast apoptosis through ROS-PI3K/AKT/GSK3β signaling pathway
by: Shuang Deng, et al.
Published: (2019-02-01)

Suppression of Virulent Porcine Epidemic Diarrhea Virus Proliferation by the PI3K/Akt/GSK-3α/β Pathway.
by: Ning Kong, et al.
Published: (2016-01-01)

Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses
by: Satoru Matsuda, et al.
Published: (2019-02-01)

PPA1 Promotes Breast Cancer Proliferation and Metastasis Through PI3K/AKT/GSK3β Signaling Pathway
by: Chunlei Guo, et al.
Published: (2021-09-01)

6-Gingerol Protects Heart by Suppressing Myocardial Ischemia/Reperfusion Induced Inflammation via the PI3K/Akt-Dependent Mechanism in Rats
by: Tongtong Xu, et al.
Published: (2018-01-01)

Divergent Roles of PI3K and Akt in Rapamycin-induced Cardioprotection against Ischemia-Reperfusion Injury
by: Desai, Shivani Kirit
Published: (2007)

Ligustilide Attenuates Ischemia Reperfusion-Induced Hippocampal Neuronal Apoptosis via Activating the PI3K/Akt Pathway
by: Qian Wu, et al.
Published: (2020-06-01)

Ischemic Postconditioning Alleviates Intestinal Ischemia-Reperfusion Injury by Enhancing Autophagy and Suppressing Oxidative Stress through the Akt/GSK-3β/Nrf2 Pathway in Mice
by: Rong Chen, et al.
Published: (2020-01-01)

Role of TLR4-Mediated PI3K/AKT/GSK-3β Signaling Pathway in Apoptosis of Rat Hepatocytes
by: Xian Zhang, et al.
Published: (2015-01-01)

KCa3.1 deficiency attenuates neuroinflammation by regulating an astrocyte phenotype switch involving the PI3K/AKT/GSK3β pathway
by: Tianjiao Wei, et al.
Published: (2019-12-01)

Corrigendum to “6-Gingerol Protects Heart by Suppressing Myocardial Ischemia/Reperfusion Induced Inflammation via the PI3K/Akt-Dependent Mechanism in Rats”
by: Tongtong Xu, et al.
Published: (2019-01-01)

Nephroprotective Effects of Polydatin against Ischemia/Reperfusion Injury: A Role for the PI3K/Akt Signal Pathway
by: Hong-Bao Liu, et al.
Published: (2015-01-01)

Mechanical Stress Regulates Osteogenesis and Adipogenesis of Rat Mesenchymal Stem Cells through PI3K/Akt/GSK-3β/β-Catenin Signaling Pathway
by: Fanglong Song, et al.
Published: (2017-01-01)

Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion
by: Jing Zhou, et al.
Published: (2015-09-01)

Acute Ethanol inhibition of γ Oscillations is mediated by Akt and GSK-3β
by: JianGang Wang, et al.
Published: (2016-08-01)