Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo

Coupling synthetic biology and chemical reactions in cells is a challenging task. The authors engineer bacteria capable of generating bromo-metabolites, develop a mild Suzuki-Miyaura cross-coupling reaction compatible with cell growth and carry out the cross-coupling chemistry in live cell cultures.

Bibliographic Details
Main Authors:	Sunil V. Sharma, Xiaoxue Tong, Cristina Pubill-Ulldemolins, Christopher Cartmell, Emma J. A. Bogosyan, Emma J. Rackham, Enrico Marelli, Refaat B. Hamed, Rebecca J. M. Goss
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-00194-3

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spelling	doaj-345055a2bdf74d8e90c9a96c8f5dc70e2021-01-31T12:24:09ZengNature Publishing GroupNature Communications2041-17232017-08-018111010.1038/s41467-017-00194-3Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivoSunil V. Sharma0Xiaoxue Tong1Cristina Pubill-Ulldemolins2Christopher Cartmell3Emma J. A. Bogosyan4Emma J. Rackham5Enrico Marelli6Refaat B. Hamed7Rebecca J. M. Goss8School of Chemistry, University of St AndrewsSchool of Chemistry, University of St AndrewsSchool of Chemistry, University of St AndrewsSchool of Chemistry, University of St AndrewsSchool of Chemistry, University of St AndrewsSchool of Chemistry, University of EastSchool of Chemistry, University of St AndrewsSchool of Chemistry, University of St AndrewsSchool of Chemistry, University of St AndrewsCoupling synthetic biology and chemical reactions in cells is a challenging task. The authors engineer bacteria capable of generating bromo-metabolites, develop a mild Suzuki-Miyaura cross-coupling reaction compatible with cell growth and carry out the cross-coupling chemistry in live cell cultures.https://doi.org/10.1038/s41467-017-00194-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sunil V. Sharma Xiaoxue Tong Cristina Pubill-Ulldemolins Christopher Cartmell Emma J. A. Bogosyan Emma J. Rackham Enrico Marelli Refaat B. Hamed Rebecca J. M. Goss
spellingShingle	Sunil V. Sharma Xiaoxue Tong Cristina Pubill-Ulldemolins Christopher Cartmell Emma J. A. Bogosyan Emma J. Rackham Enrico Marelli Refaat B. Hamed Rebecca J. M. Goss Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo Nature Communications
author_facet	Sunil V. Sharma Xiaoxue Tong Cristina Pubill-Ulldemolins Christopher Cartmell Emma J. A. Bogosyan Emma J. Rackham Enrico Marelli Refaat B. Hamed Rebecca J. M. Goss
author_sort	Sunil V. Sharma
title	Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo
title_short	Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo
title_full	Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo
title_fullStr	Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo
title_full_unstemmed	Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo
title_sort	living genochemetics by hyphenating synthetic biology and synthetic chemistry in vivo
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-08-01
description	Coupling synthetic biology and chemical reactions in cells is a challenging task. The authors engineer bacteria capable of generating bromo-metabolites, develop a mild Suzuki-Miyaura cross-coupling reaction compatible with cell growth and carry out the cross-coupling chemistry in live cell cultures.
url	https://doi.org/10.1038/s41467-017-00194-3
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Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo

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