Diagnostic assessment of endothelial function in metabolic syndrome and coronary heart disease

Aim. To study the endothelial status, endothelial relaxation and constriction reserve, inflammation markers, and adipokines in men with metabolic syndrome (MS) and various forms of coronary heart disease (CHD). Material and methods. In total, 236 male patients (mean age 56,5±2,07 years) were followe...

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Main Authors: V. A. Nevzorova, O. V. Nastradin, O. G. Pomogalova, E. S. Potapova
Format: Article
Language:Russian
Published: «SILICEA-POLIGRAF» LLC 2011-04-01
Series:Кардиоваскулярная терапия и профилактика
Subjects:
Online Access:https://cardiovascular.elpub.ru/jour/article/view/1744
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spelling doaj-344b36a90bdd4c2dabb4e758cb72101a2021-07-28T13:50:52Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252011-04-01102818710.15829/1728-8800-2011-2-81-871462Diagnostic assessment of endothelial function in metabolic syndrome and coronary heart diseaseV. A. Nevzorova0O. V. Nastradin1O. G. Pomogalova2E. S. Potapova3Vladivostok State Medical UniversityVladivostok State Medical UniversityCity Clinical Hospital No. 1Vladivostok State Medical UniversityAim. To study the endothelial status, endothelial relaxation and constriction reserve, inflammation markers, and adipokines in men with metabolic syndrome (MS) and various forms of coronary heart disease (CHD). Material and methods. In total, 236 male patients (mean age 56,5±2,07 years) were followed up. Serum levels of NO metabolites (NOnˉ), endothelin-1 (ET-1), and C-reactive protein (CRP) were measured, as well as the levels of cytokine system components (interleukin (IL) 6 and 10), tumor necrosis factor (TNF) alpha, and adipokines (leptin and adiponectin). Results. Endothelial dysfunction was manifested in reduced levels of NO metabolites in MS and additional increase of serum ET-1 concentration in CHD. Serum CRP levels were increased in MS and CHD, being maximal in patients with Q-wave myocardial infarction (MI). In MI patients, the levels of TNF-alpha and IL-10 were decreased, while IL-6 concentration was elevated. Leptin concentration was increased in participants with MS only, or the combination of MI and MS. Adiponectin levels were decreased in MI patients, regardless of MS presence or absence. Conclusion. The combination of MS and CHD was characterised by endothelial dysfunction. Serum inflammatory activity (increased CRP levels) was elevated in MS and was maximal in Q-wave MI. Serum levels of adipokines were dependent on MS presence or absence, with increased leptin concentration both at the risk factor stage and the Q-wave MI stage.https://cardiovascular.elpub.ru/jour/article/view/1744metabolic syndromecoronary heart diseaseendothelial dysfunctioncytokinesadipokines
collection DOAJ
language Russian
format Article
sources DOAJ
author V. A. Nevzorova
O. V. Nastradin
O. G. Pomogalova
E. S. Potapova
spellingShingle V. A. Nevzorova
O. V. Nastradin
O. G. Pomogalova
E. S. Potapova
Diagnostic assessment of endothelial function in metabolic syndrome and coronary heart disease
Кардиоваскулярная терапия и профилактика
metabolic syndrome
coronary heart disease
endothelial dysfunction
cytokines
adipokines
author_facet V. A. Nevzorova
O. V. Nastradin
O. G. Pomogalova
E. S. Potapova
author_sort V. A. Nevzorova
title Diagnostic assessment of endothelial function in metabolic syndrome and coronary heart disease
title_short Diagnostic assessment of endothelial function in metabolic syndrome and coronary heart disease
title_full Diagnostic assessment of endothelial function in metabolic syndrome and coronary heart disease
title_fullStr Diagnostic assessment of endothelial function in metabolic syndrome and coronary heart disease
title_full_unstemmed Diagnostic assessment of endothelial function in metabolic syndrome and coronary heart disease
title_sort diagnostic assessment of endothelial function in metabolic syndrome and coronary heart disease
publisher «SILICEA-POLIGRAF» LLC
series Кардиоваскулярная терапия и профилактика
issn 1728-8800
2619-0125
publishDate 2011-04-01
description Aim. To study the endothelial status, endothelial relaxation and constriction reserve, inflammation markers, and adipokines in men with metabolic syndrome (MS) and various forms of coronary heart disease (CHD). Material and methods. In total, 236 male patients (mean age 56,5±2,07 years) were followed up. Serum levels of NO metabolites (NOnˉ), endothelin-1 (ET-1), and C-reactive protein (CRP) were measured, as well as the levels of cytokine system components (interleukin (IL) 6 and 10), tumor necrosis factor (TNF) alpha, and adipokines (leptin and adiponectin). Results. Endothelial dysfunction was manifested in reduced levels of NO metabolites in MS and additional increase of serum ET-1 concentration in CHD. Serum CRP levels were increased in MS and CHD, being maximal in patients with Q-wave myocardial infarction (MI). In MI patients, the levels of TNF-alpha and IL-10 were decreased, while IL-6 concentration was elevated. Leptin concentration was increased in participants with MS only, or the combination of MI and MS. Adiponectin levels were decreased in MI patients, regardless of MS presence or absence. Conclusion. The combination of MS and CHD was characterised by endothelial dysfunction. Serum inflammatory activity (increased CRP levels) was elevated in MS and was maximal in Q-wave MI. Serum levels of adipokines were dependent on MS presence or absence, with increased leptin concentration both at the risk factor stage and the Q-wave MI stage.
topic metabolic syndrome
coronary heart disease
endothelial dysfunction
cytokines
adipokines
url https://cardiovascular.elpub.ru/jour/article/view/1744
work_keys_str_mv AT vanevzorova diagnosticassessmentofendothelialfunctioninmetabolicsyndromeandcoronaryheartdisease
AT ovnastradin diagnosticassessmentofendothelialfunctioninmetabolicsyndromeandcoronaryheartdisease
AT ogpomogalova diagnosticassessmentofendothelialfunctioninmetabolicsyndromeandcoronaryheartdisease
AT espotapova diagnosticassessmentofendothelialfunctioninmetabolicsyndromeandcoronaryheartdisease
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