The Role of the C-Clamp in Wnt-Related Colorectal Cancers
T-cell Factor/Lymphoid Enhancer Factor (TCF/LEF) transcription factors are major regulators of Wnt targets, and the products of the TCF7 and TCF7L2 genes have both been implicated in the progression of colorectal cancer in animal models and humans. TCFs recognize specific DNA sequences through their...
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| Format: | Article |
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MDPI AG
2016-08-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/8/8/74 |
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doaj-344af5eb3334477c9f05e4cfc5523cf42020-11-24T22:24:04ZengMDPI AGCancers2072-66942016-08-01887410.3390/cancers8080074cancers8080074The Role of the C-Clamp in Wnt-Related Colorectal CancersAditi J. Ravindranath0Ken M. Cadigan1Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USADepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USAT-cell Factor/Lymphoid Enhancer Factor (TCF/LEF) transcription factors are major regulators of Wnt targets, and the products of the TCF7 and TCF7L2 genes have both been implicated in the progression of colorectal cancer in animal models and humans. TCFs recognize specific DNA sequences through their high mobility group (HMG) domains, but invertebrate TCFs and some isoforms of vertebrate TCF7 and TCF7L2 contain a second DNA binding domain known as the C-clamp. This review will cover the basic properties of C-clamps and their importance in Wnt signaling, using data from Drosophila, C. elegans, and mammalian cell culture. The connection between C-clamp containing TCFs and colorectal cancer will also be discussed.http://www.mdpi.com/2072-6694/8/8/74TCF/LEFC-clampWntβ-catenincolorectal cancer |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Aditi J. Ravindranath Ken M. Cadigan |
| spellingShingle |
Aditi J. Ravindranath Ken M. Cadigan The Role of the C-Clamp in Wnt-Related Colorectal Cancers Cancers TCF/LEF C-clamp Wnt β-catenin colorectal cancer |
| author_facet |
Aditi J. Ravindranath Ken M. Cadigan |
| author_sort |
Aditi J. Ravindranath |
| title |
The Role of the C-Clamp in Wnt-Related Colorectal Cancers |
| title_short |
The Role of the C-Clamp in Wnt-Related Colorectal Cancers |
| title_full |
The Role of the C-Clamp in Wnt-Related Colorectal Cancers |
| title_fullStr |
The Role of the C-Clamp in Wnt-Related Colorectal Cancers |
| title_full_unstemmed |
The Role of the C-Clamp in Wnt-Related Colorectal Cancers |
| title_sort |
role of the c-clamp in wnt-related colorectal cancers |
| publisher |
MDPI AG |
| series |
Cancers |
| issn |
2072-6694 |
| publishDate |
2016-08-01 |
| description |
T-cell Factor/Lymphoid Enhancer Factor (TCF/LEF) transcription factors are major regulators of Wnt targets, and the products of the TCF7 and TCF7L2 genes have both been implicated in the progression of colorectal cancer in animal models and humans. TCFs recognize specific DNA sequences through their high mobility group (HMG) domains, but invertebrate TCFs and some isoforms of vertebrate TCF7 and TCF7L2 contain a second DNA binding domain known as the C-clamp. This review will cover the basic properties of C-clamps and their importance in Wnt signaling, using data from Drosophila, C. elegans, and mammalian cell culture. The connection between C-clamp containing TCFs and colorectal cancer will also be discussed. |
| topic |
TCF/LEF C-clamp Wnt β-catenin colorectal cancer |
| url |
http://www.mdpi.com/2072-6694/8/8/74 |
| work_keys_str_mv |
AT aditijravindranath theroleofthecclampinwntrelatedcolorectalcancers AT kenmcadigan theroleofthecclampinwntrelatedcolorectalcancers AT aditijravindranath roleofthecclampinwntrelatedcolorectalcancers AT kenmcadigan roleofthecclampinwntrelatedcolorectalcancers |
| _version_ |
1725762502076137472 |