Monitoring cisplatin-induced ototoxicity.

• Main Authors: Ana SÁNCHEZ-MARTÍNEZ, José Ignacio BENITO-OREJAS, Juan José TAVÁREZ-RODRÍGUEZ, María Lourdes HERNÁNDEZ-SANTOS, Darío MORAIS-PÉREZ, Diego SOTO-PRADO
• Format: Article
• Language: Spanish
• Published: Ediciones Universidad de Salamanca 2018-03-01
• Series: Revista ORL
• Subjects: estudios de seguimiento; monitorización auditiva; ototoxicidad; cisplatino; hipoacusia; otoemisiones acústicas.
• Online Access: https://revistas.usal.es/index.php/2444-7986/article/view/16774

Introduction and objective: The ototoxic damage goes unnoticed to disabling levels, being justified to apply control for its early detection procedures, make it possible to a therapeutic change and if necessary, a speech and auditory rehabilitation. The objective of this study will consist to present Protocol we did at the Hospital Clínico Universitario de Valladolid for the follow-up of the patients treated with cisplatin. Method: Ototoxicity monitoring means serially collect hearing thresholds. It is identified on a visit if hearing has worsened in some ear. The comparison allows to detect the change and indicate if it is significant or not in relation to some criteria. We will also evaluate the occurrence of vestibular damage. As auditory monitoring procedures, we will use high frequency audiometry and acoustic oto-emissions. Results: After giving informed consent and a brief medical history we started with baseline assessment of hearing, prior to treatment, continuing with periodic reviews before each cycle. If any change is detected it is reported to the physician and the patient. To grade the ototoxicity, we apply the Brock and Chang criteria. We maintain post-treatment control. Discussion and conclusion: The incidence of ototoxicity of cisplatin is unknown in our country and it is not possible to predict which patients will experience. The increase in the survival rate for cancer involves improving comorbidity, which in the case of its early ototoxicity supposed to find the best solutions to restore the quality of life of patient’s detection.