The auto-inhibitory role of the EPAC hinge helix as mapped by NMR.

The auto-inhibitory role of the EPAC hinge helix as mapped by NMR.

The cyclic-AMP binding domain (CBD) is the central regulatory unit of exchange proteins activated by cAMP (EPAC). The CBD maintains EPAC in a state of auto-inhibition in the absence of the allosteric effector, cAMP. When cAMP binds to the CBD such auto-inhibition is released, leading to EPAC activat...

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Bibliographic Details
Main Authors: Rajeevan Selvaratnam, Mohammad T Mazhab-Jafari, Rahul Das, Giuseppe Melacini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3504058?pdf=render

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