Inferring HIV escape rates from multi-locus genotype data

Inferring HIV escape rates from multi-locus genotype data

Cytotoxic T-lymphocytes (CTLs) recognize viral protein fragments displayed by major histocompatibility complex (MHC) molecules on the surface of virally infected cells and generate an anti-viral response that can kill the infected cells. Virus variants whose protein fragments are not efficiently pre...

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Bibliographic Details
Main Authors: Taylor A Kessinger, Alan S Perelson, Richard A Neher
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Immunology
Subjects:
HIV
cytotoxic T lymphocytes
viral dynamics
selection coefficient
CTL escape
HIV evolution
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00252/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00252/full

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