c-Myc and AMPK Control Cellular Energy Levels by Cooperatively Regulating Mitochondrial Structure and Function.

c-Myc and AMPK Control Cellular Energy Levels by Cooperatively Regulating Mitochondrial Structure and Function.

The c-Myc (Myc) oncoprotein and AMP-activated protein kinase (AMPK) regulate glycolysis and oxidative phosphorylation (Oxphos) although often for different purposes. Because Myc over-expression depletes ATP with the resultant activation of AMPK, we explored the potential co-dependency of and cross-t...

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Main Authors: Lia R Edmunds, Lokendra Sharma, Huabo Wang, Audry Kang, Sonia d'Souza, Jie Lu, Michael McLaughlin, James M Dolezal, Xiaoli Gao, Susan T Weintraub, Ying Ding, Xuemei Zeng, Nathan Yates, Edward V Prochownik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4521957?pdf=render

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