Tuberculose multi-resistente. A propósito de um caso clínico de reinfeção exógena adquirida no meio prisional

• Main Authors: José Leon Bernardo, Ana Galiano, Laura Brum, Isabel Portugal
• Format: Article
• Language: English
• Published: Elsevier 1998-05-01
• Series: Revista Portuguesa de Pneumologia
• Online Access: http://www.sciencedirect.com/science/article/pii/S0873215915310503
• ISSN: 0873-2159

RESUMO: Os autores descrevem um caso clinic de tuberculose multi-resistente num doente recluse, toxicodependente e com SIDA que se encontrava sob terapêutiea antibacilar em virtude de anterior episodin de tuberculose âsendivelâ.Comentam alguns aspectos relacionadus com o diagnostic, tratamento e evoução exógena por estirpe multi-resistente.Em conclusão, us autores salientam o interesse do DNA âfingerprintingâ no diagnostic e epidemiologia da tuberculose multi-resistente e a necessidade de implementação de um efectivo programa de luta contra a tuberculose multi-resistente na comunidade prisional.REV PORT PNEUMOL 1998; IV (3): 319-325 ARSTRACT: A case of multidrug-resistant tuberculosis in a drug-addicted and jailed patient with AIDS is reported. The patient was in anti-tuberculosis therapy, because a question of ongoing âsensitiveâ tuberculosis.The authors comment some aspects of the clinical management of the patient. Exogenous reinfection with a multidrug-resistant strain was convincelly demonstrated with DNA fingerprinting.The relevance of DNA fingerprinting in the diagnosis and epidemiology of multidrug-resistant tuberculosis is emphasized and the reformulation of the anti-tuberculosis programme in the prisional setting is warranted, in the face of ongoing transmissionREV PORT PNEUMOL 1998; IV (3): 319-325 Palavras-chave: Tuberculose multirresistente, RFLP, Key-words: Multidrug-resistant tuberculosis (MDR-TB), RELP