High Dietary Iron Supplement Induces the Nigrostriatal Dopaminergic Neurons Lesion in Transgenic Mice Expressing Mutant A53T Human Alpha-Synuclein

High Dietary Iron Supplement Induces the Nigrostriatal Dopaminergic Neurons Lesion in Transgenic Mice Expressing Mutant A53T Human Alpha-Synuclein

Both alpha-synuclein aggregation and iron deposits are neuropathological hallmarks of Parkinson’s disease (PD). We are particularly interested in whether iron could synergize with alpha-synuclein pathology in vivo, especially in the nigrostriatal system. In the present study, we reported transgenic...

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Bibliographic Details
Main Authors: Fengju Jia, Ning Song, Weiwei Wang, Xixun Du, Yajing Chi, Hong Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
iron
alpha-synuclein
substantia nigra
Parkinson’s disease
aging
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2018.00097/full

Internet

http://journal.frontiersin.org/article/10.3389/fnagi.2018.00097/full

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