Expression of EGFR and Molecules Downstream to PI3K/Akt, Raf-1-MEK-1-MAP (Erk1/2), and JAK (STAT3) Pathways in Invasive Lung Adenocarcinomas Resected at a Single Institution

Expression of EGFR and Molecules Downstream to PI3K/Akt, Raf-1-MEK-1-MAP (Erk1/2), and JAK (STAT3) Pathways in Invasive Lung Adenocarcinomas Resected at a Single Institution

Therapies targeting EGFR are effective in treating tumors that harbor molecular alterations; however, there is heterogeneity in long-term response to these therapies. We retrospectively analyzed protein expression of EGFR, Stat3, phospho-Akt, and phospho-Erk1/2 by immunohistochemistry in a series of...

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Bibliographic Details
Main Authors: Alba Fabiola Torres, Cleto Nogueira, Juliana Magalhaes, Igor Santos Costa, Alessa Aragao, Antero Gomes Neto, Filadelfia Martins, Fabio Tavora
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Analytical Cellular Pathology
Online Access:http://dx.doi.org/10.1155/2014/352925

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