Pathway analysis of rare variants for the clustered phenotypes by using hierarchical structured components analysis

Pathway analysis of rare variants for the clustered phenotypes by using hierarchical structured components analysis

Abstract Backgrounds Recent large-scale genetic studies often involve clustered phenotypes such as repeated measurements. Compared to a series of univariate analyses of single phenotypes, an analysis of clustered phenotypes can be useful for substantially increasing statistical power to detect more...

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Bibliographic Details
Main Authors: Sungyoung Lee, Sunmee Kim, Yongkang Kim, Bermseok Oh, Heungsun Hwang, Taesung Park
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Medical Genomics
Subjects:
Generalized estimating equations
Clustered phenotypes
Pathway analysis
Rare variants
Online Access:http://link.springer.com/article/10.1186/s12920-019-0517-4

Internet

http://link.springer.com/article/10.1186/s12920-019-0517-4

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