Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges

Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges

Trypanosoma cruzi infects humans when infected triatomine vector excreta contaminate breaks in skin or mucosal surfaces. T. cruzi insect-derived metacyclic trypomastigotes (IMT) invade through gastric mucosa after oral challenges without any visible inflammatory changes, while cutaneous and conjunct...

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Bibliographic Details
Main Authors: Christopher Steven Eickhoff, Brian Anthony Dunn, Nicole Lea Sullivan, Daniel Fredric Hoft
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2013-06-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Trypanosoma cruzi
mucosal immunity
Chagas disease
animal disease models
infection control
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000400508&lng=en&tlng=en

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