Single administration of ultra-low-dose lipopolysaccharide in rat early pregnancy induces TLR4 activation in the placenta contributing to preeclampsia.

Single administration of ultra-low-dose lipopolysaccharide in rat early pregnancy induces TLR4 activation in the placenta contributing to preeclampsia.

Balanced immune responses are essential for the maintenance of successful pregnancy. Aberrant responses of immune system during pregnancy increase the risk of preeclampsia. Toll-like receptor 4 (TLR4) plays a crucial role in the activation of immune system at the maternal-fetal interface. This study...

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Bibliographic Details
Main Authors: Pingping Xue, Mingming Zheng, Ping Gong, Caimei Lin, Jianjun Zhou, Yujing Li, Li Shen, Zhenyu Diao, Guijun Yan, Haixiang Sun, Yali Hu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4390151?pdf=render

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http://europepmc.org/articles/PMC4390151?pdf=render

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