Chitosan-silica Sulfate Nano Hybrid: An Efficient Biopolymer Based-heterogeneous Nano Catalyst for Solvent-free Synthesis of 3,4-Dihydropyrimidine-2(1H)-one/thiones

A green and highly efficient approach for the synthesis of 3,4-dihydropyrimidine-2(1H)-one/thione derivatives is described. In this approach, the three-component Biginelli reaction between (thio)urea, methyl acetoacetate and aldehydes under solvent-free condition in the presence of chitosan-silica s...

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Main Authors:	Somayeh Behrouz, Masoome Nazar Abi, Mohammad Amin Piltan
Format:	Article
Language:	English
Published:	Slovenian Chemical Society 2021-06-01
Series:	Acta Chimica Slovenica
Subjects:	chitosan-silica sulfate nano hybrid 3,4-dihydropyrimidines green chemistry heterogeneous catalysis multicomponent reaction
Online Access:	https://journals.matheo.si/index.php/ACSi/article/view/6343

id	doaj-34117748d30d4728b633865b19c217b5
record_format	Article
spelling	doaj-34117748d30d4728b633865b19c217b52021-08-25T11:23:40ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552021-06-0168237438610.17344/acsi.2020.6343962Chitosan-silica Sulfate Nano Hybrid: An Efficient Biopolymer Based-heterogeneous Nano Catalyst for Solvent-free Synthesis of 3,4-Dihydropyrimidine-2(1H)-one/thionesSomayeh Behrouz0Masoome Nazar Abi1Mohammad Amin Piltan2Medicinal Chemistry Research Laboratory, Department of Chemistry, Shiraz University of Technology, Shiraz 71555-313, IranMedicinal Chemistry Research Laboratory, Department of Chemistry, Shiraz University of Technology, Shiraz 71555-313, IranMedicinal Chemistry Research Laboratory, Department of Chemistry, Shiraz University of Technology, Shiraz 71555-313, IranA green and highly efficient approach for the synthesis of 3,4-dihydropyrimidine-2(1H)-one/thione derivatives is described. In this approach, the three-component Biginelli reaction between (thio)urea, methyl acetoacetate and aldehydes under solvent-free condition in the presence of chitosan-silica sulfate nano hybrid (CSSNH) as a green and heterogeneous nano catalyst affords the corresponding products in good to excellent yields and in short reaction times. CSSNH is a cheap, eco-friendly, and non-toxic nano catalyst that could be easily prepared, handled, and reused for many reaction runs without significant loss of its activity.https://journals.matheo.si/index.php/ACSi/article/view/6343chitosan-silica sulfate nano hybrid3,4-dihydropyrimidinesgreen chemistryheterogeneous catalysismulticomponent reaction
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Somayeh Behrouz Masoome Nazar Abi Mohammad Amin Piltan
spellingShingle	Somayeh Behrouz Masoome Nazar Abi Mohammad Amin Piltan Chitosan-silica Sulfate Nano Hybrid: An Efficient Biopolymer Based-heterogeneous Nano Catalyst for Solvent-free Synthesis of 3,4-Dihydropyrimidine-2(1H)-one/thiones Acta Chimica Slovenica chitosan-silica sulfate nano hybrid 3,4-dihydropyrimidines green chemistry heterogeneous catalysis multicomponent reaction
author_facet	Somayeh Behrouz Masoome Nazar Abi Mohammad Amin Piltan
author_sort	Somayeh Behrouz
title	Chitosan-silica Sulfate Nano Hybrid: An Efficient Biopolymer Based-heterogeneous Nano Catalyst for Solvent-free Synthesis of 3,4-Dihydropyrimidine-2(1H)-one/thiones
title_short	Chitosan-silica Sulfate Nano Hybrid: An Efficient Biopolymer Based-heterogeneous Nano Catalyst for Solvent-free Synthesis of 3,4-Dihydropyrimidine-2(1H)-one/thiones
title_full	Chitosan-silica Sulfate Nano Hybrid: An Efficient Biopolymer Based-heterogeneous Nano Catalyst for Solvent-free Synthesis of 3,4-Dihydropyrimidine-2(1H)-one/thiones
title_fullStr	Chitosan-silica Sulfate Nano Hybrid: An Efficient Biopolymer Based-heterogeneous Nano Catalyst for Solvent-free Synthesis of 3,4-Dihydropyrimidine-2(1H)-one/thiones
title_full_unstemmed	Chitosan-silica Sulfate Nano Hybrid: An Efficient Biopolymer Based-heterogeneous Nano Catalyst for Solvent-free Synthesis of 3,4-Dihydropyrimidine-2(1H)-one/thiones
title_sort	chitosan-silica sulfate nano hybrid: an efficient biopolymer based-heterogeneous nano catalyst for solvent-free synthesis of 3,4-dihydropyrimidine-2(1h)-one/thiones
publisher	Slovenian Chemical Society
series	Acta Chimica Slovenica
issn	1318-0207 1580-3155
publishDate	2021-06-01
description	A green and highly efficient approach for the synthesis of 3,4-dihydropyrimidine-2(1H)-one/thione derivatives is described. In this approach, the three-component Biginelli reaction between (thio)urea, methyl acetoacetate and aldehydes under solvent-free condition in the presence of chitosan-silica sulfate nano hybrid (CSSNH) as a green and heterogeneous nano catalyst affords the corresponding products in good to excellent yields and in short reaction times. CSSNH is a cheap, eco-friendly, and non-toxic nano catalyst that could be easily prepared, handled, and reused for many reaction runs without significant loss of its activity.
topic	chitosan-silica sulfate nano hybrid 3,4-dihydropyrimidines green chemistry heterogeneous catalysis multicomponent reaction
url	https://journals.matheo.si/index.php/ACSi/article/view/6343
work_keys_str_mv	AT somayehbehrouz chitosansilicasulfatenanohybridanefficientbiopolymerbasedheterogeneousnanocatalystforsolventfreesynthesisof34dihydropyrimidine21honethiones AT masoomenazarabi chitosansilicasulfatenanohybridanefficientbiopolymerbasedheterogeneousnanocatalystforsolventfreesynthesisof34dihydropyrimidine21honethiones AT mohammadaminpiltan chitosansilicasulfatenanohybridanefficientbiopolymerbasedheterogeneousnanocatalystforsolventfreesynthesisof34dihydropyrimidine21honethiones
_version_	1721196506319421440

Chitosan-silica Sulfate Nano Hybrid: An Efficient Biopolymer Based-heterogeneous Nano Catalyst for Solvent-free Synthesis of 3,4-Dihydropyrimidine-2(1H)-one/thiones

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