Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells

Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells

Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the hypothesis that lactate could function as an oncometabolite by evaluating whether lactate exposure modifies the expression of oncogenes, or genes encoding transcription factors, cell division, and cell pro...

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Bibliographic Details
Main Authors: Iñigo San-Millán, Colleen G. Julian, Christopher Matarazzo, Janel Martinez, George A. Brooks
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Oncology
Subjects:
lactate
cancer
oncogenes
transcription factors
cell cycle genes
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01536/full

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