Multivariate Quantification of the Solid State Phase Composition of Co-Amorphous Naproxen-Indomethacin

Multivariate Quantification of the Solid State Phase Composition of Co-Amorphous Naproxen-Indomethacin

To benefit from the optimized dissolution properties of active pharmaceutical ingredients in their amorphous forms, co-amorphisation as a viable tool to stabilize these amorphous phases is of both academic and industrial interest. Reports dealing with the physical stability and recrystallization beh...

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Bibliographic Details
Main Authors: Andreas Beyer, Holger Grohganz, Korbinian Löbmann, Thomas Rades, Claudia S. Leopold
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Molecules
Subjects:
co-amorphous
solid state analysis
composition
multivariate
PLS
XRPD
recrystallization
stability
Online Access:http://www.mdpi.com/1420-3049/20/10/19571

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