Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin Resistance

Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin Resistance

Insulin resistance and type 2 diabetes are associated with hepatitis C virus infection. A wealth of clinical and experimental data suggests that the virus is directly interfering with the insulin signalling in hepatocytes. In the case of at least one viral genotype (the type 3a), insulin resistance...

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Main Author: Francesco Negro
Format: Article
Language:English
Published: Hindawi Limited 2009-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/2009/483485
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spelling doaj-34041ded05aa4fe1990815b3fca25efe2020-11-24T23:13:56ZengHindawi LimitedPPAR Research1687-47571687-47652009-01-01200910.1155/2009/483485483485Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin ResistanceFrancesco Negro0Viropathology Unit, University of Geneva Medical Center, 1211 Geneva, SwitzerlandInsulin resistance and type 2 diabetes are associated with hepatitis C virus infection. A wealth of clinical and experimental data suggests that the virus is directly interfering with the insulin signalling in hepatocytes. In the case of at least one viral genotype (the type 3a), insulin resistance seems to be directly mediated by the downregulation of the peroxisome proliferator-activated receptor γ. Whether and how this interaction may be manipulated pharmacologically, in order to improve the responsiveness to antivirals of insulin resistant chronic hepatitis C, patients remain to be fully explored.http://dx.doi.org/10.1155/2009/483485
collection DOAJ
language English
format Article
sources DOAJ
author Francesco Negro
spellingShingle Francesco Negro
Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin Resistance
PPAR Research
author_facet Francesco Negro
author_sort Francesco Negro
title Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin Resistance
title_short Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin Resistance
title_full Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin Resistance
title_fullStr Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin Resistance
title_full_unstemmed Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin Resistance
title_sort peroxisome proliferator-activated receptors and hepatitis c virus-induced insulin resistance
publisher Hindawi Limited
series PPAR Research
issn 1687-4757
1687-4765
publishDate 2009-01-01
description Insulin resistance and type 2 diabetes are associated with hepatitis C virus infection. A wealth of clinical and experimental data suggests that the virus is directly interfering with the insulin signalling in hepatocytes. In the case of at least one viral genotype (the type 3a), insulin resistance seems to be directly mediated by the downregulation of the peroxisome proliferator-activated receptor γ. Whether and how this interaction may be manipulated pharmacologically, in order to improve the responsiveness to antivirals of insulin resistant chronic hepatitis C, patients remain to be fully explored.
url http://dx.doi.org/10.1155/2009/483485
work_keys_str_mv AT francesconegro peroxisomeproliferatoractivatedreceptorsandhepatitiscvirusinducedinsulinresistance
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